diff --git a/Dockerfile b/Dockerfile new file mode 100644 index 0000000..69165be --- /dev/null +++ b/Dockerfile @@ -0,0 +1,17 @@ +FROM python:3.11-slim + +ENV PYTHONDONTWRITEBYTECODE=1 \ + PYTHONUNBUFFERED=1 \ + PIP_NO_CACHE_DIR=1 + +WORKDIR /app + +COPY . /app + +RUN pip install --upgrade pip \ + && pip install streamlit pandas plotly networkx neo4j + +EXPOSE 8501 + +CMD ["bash", "-c", "python etl.py || true && exec streamlit run dashboard.py --server.port=8501 --server.address=0.0.0.0"] + diff --git a/README.md b/README.md index d318163..56f3968 100644 --- a/README.md +++ b/README.md @@ -8,13 +8,13 @@ A comprehensive ETL pipeline and interactive dashboard for analyzing biomedical - [Features](#features) - [Prerequisites](#prerequisites) - [Installation](#installation) -- [Usage](#usage) - [Project Structure](#project-structure) - [Data Analyses](#data-analyses) - [Dashboard Features](#dashboard-features) - [Output Files](#output-files) - [Technical Details](#technical-details) - +- [Neo4j ETL & Analysis Pipeline](#neo4j-etl--analysis-pipeline) + ## Overview This project implements a complete data pipeline for the Hetionet knowledge graph, consisting of: @@ -82,7 +82,7 @@ networkx>=3.0 ## Installation -### 1. Clone or Download Project Files +### Clone or Download Project Files ```bash # Create project directory @@ -90,7 +90,48 @@ mkdir hetionet_analysis cd hetionet_analysis ``` -### 2. Set Up Python Environment +### (Optional) Docker Setup for Dashboard + +You can run the Streamlit dashboard in a Docker container for easier deployment. + +Dockerfile example (already present in project root) + +```bash +FROM python:3.11-slim + +ENV PYTHONDONTWRITEBYTECODE=1 \ + PYTHONUNBUFFERED=1 \ + PIP_NO_CACHE_DIR=1 + +WORKDIR /app + +COPY . /app + +RUN pip install --upgrade pip \ + && pip install streamlit pandas plotly networkx neo4j + +EXPOSE 8501 + +CMD ["bash", "-c", "python etl.py || true && exec streamlit run dashboard.py --server.port=8501 --server.address=0.0.0.0"] + + +``` + +Build Docker image + +```bash +docker build -t etl-dashboard . +``` + +Run etl and dashboard in Docker + +```bash +docker run -p 8501:8501 etl-dashboard +``` + +## Non Docker usage + +### 1. Set Up Python Environment ```bash # Create virtual environment @@ -106,34 +147,21 @@ source etl_projekt/bin/activate pip install pandas streamlit plotly networkx ``` -### 3. Download Hetionet Data - -Download `hetionet-v1.0.json` from [Hetionet GitHub](https://github.com/hetio/hetionet) and place it in the project directory. - -### 4. Add Project Files - -Place the following files in your project directory: - -- `hetionet_etl_final.py` - Main ETL script -- `dashboard.py` - Streamlit dashboard - -## Usage - -### Step 1: Run ETL Pipeline +### 2. Run ETL Pipeline Execute the ETL pipeline to process the Hetionet data: ```bash -python hetionet_etl_final.py +python etl.py ``` -**Expected Runtime**: 1-2 minutes +**Expected Runtime**: ~ 1 minute -**Output**: Creates `neo4j_csv/` directory with 20 CSV files +**Output**: Creates `neo4j_csv/` directory with CSV files -### Step 2: Launch Dashboard +### 3. Launch Dashboard -Start the interactive dashboard: +Directly with Python ```bash streamlit run dashboard.py @@ -141,7 +169,7 @@ streamlit run dashboard.py The dashboard will automatically open in your web browser at `http://localhost:8501` -### Step 3: Explore Data +## Explore Data Navigate through the dashboard using the sidebar menu: @@ -165,6 +193,7 @@ hetionet_analysis/ ├── neo4j_csv/ # Generated output directory │ ├── nodes_*.csv # Node files by type (11 files) │ ├── edges_all.csv # All relationships +| |── edges_*.csv # Splitted relationsship for neo4j import │ ├── analysis_*.csv # Analysis results (6 files) │ ├── network_nodes.csv # Network visualization nodes │ └── network_edges.csv # Network visualization edges @@ -375,16 +404,6 @@ edges_df['target'] = edges_df['target'].astype(str) This prevents type mismatch errors when joining dataframes. -### Memory Management - -Peak memory usage: ~2GB during ETL processing - -**Optimization strategies**: - -- Process data in chunks where possible -- Drop intermediate dataframes after use -- Use generators for large iterations - ### Edge Direction Conventions Hetionet uses directional relationships. Key conventions: @@ -398,28 +417,6 @@ Hetionet uses directional relationships. Key conventions: Current implementation handles Hetionet v1.0 (47K nodes, 2.2M edges). -For larger datasets: - -- Implement chunked CSV reading -- Use database backend (PostgreSQL, Neo4j) -- Parallelize analyses with multiprocessing - -## Troubleshooting - -### Common Issues - -**Issue**: "FileNotFoundError: hetionet-v1.0.json" -**Solution**: Download Hetionet data and place in project directory - -**Issue**: "Module not found" -**Solution**: Ensure virtual environment is activated and dependencies installed - -**Issue**: Dashboard shows "No data available" -**Solution**: Run ETL pipeline first to generate CSV files - -**Issue**: "Memory Error" during ETL -**Solution**: Close other applications or increase system RAM - ### Data Quality The analyses depend on Hetionet data quality. Known limitations: @@ -428,16 +425,79 @@ The analyses depend on Hetionet data quality. Known limitations: - Gene-disease associations vary in evidence strength - Network is not exhaustive of all biomedical knowledge +## Neo4j ETL & Analysis Pipeline + +This repository includes a script for executing analysis queries on the dataset in a Neo4j database. + +### Neo4j Prerequisites + +Ensure that the following components are installed and ready to use: + +- **Neo4j Desktop:** A local database instance must be created. +- **Python 3.x:** Installed on your system. +- **Python Driver:** Install the official Neo4j driver via pip in your virtual environment you created earlier: + + ```bash + pip install neo4j + ``` + +--- + +## Workflow Steps + +Follow these steps exactly in the order provided: + +### 1. Start Neo4j Database + + Open **Neo4j Desktop**. + Select your project and click **Start** on the corresponding database. + The database must be active before proceeding to the next steps. + +### 2. Copy CSV Files + + After your ETL process has generated the CSV files, they must be moved to the Neo4j import directory. + **Locating the path:** In Neo4j Desktop, click on `Open Folder` -> `Import`. + Copy all CSV files from your ETL output into this folder. + +### 3. Data Import via Cypher + + Navigate to the folder `neo4jqueries/loadingQueriesNeo4j`. + Execute the Cypher scripts contained there within the **Neo4j Browser**. + These scripts load the data from the import folder and create the nodes and relationships in the graph. + +### 4. Execute Python Analysis + + Start the analysis script via your terminal: + +```bash +python neo4j_etl.py +``` + + **Eingabe:** Das Skript wird Sie nacheinander nach Ihrem **Datenbank-Usernamen** (Standard: `neo4j`) und Ihrem **Passwort** fragen. + **Verarbeitung:** Das Skript liest automatisch alle Abfragen aus dem Verzeichnis `neo4jqueries/analysis_queries` aus. + **Ausgabe:** Die Ergebnisse der Analyse-Queries werden direkt in der Konsole ausgegeben. + +--- + +### Projektstruktur + +| Verzeichnis / Datei | Funktion | +| :---------------------------------- | :--------------------------------------------------------- | +| `neo4j_etl.py` | Das Python-Skript zur Ausführung der Analyse-Queries. | +| `neo4jqueries/loadingQueriesNeo4j/` | Enthält alle Cypher-Dateien für den initialen Datenimport. | +| `neo4jqueries/analysis_queries/` | Enthält Cypher-Dateien für die statistische Auswertung. | + +--- + ## Future Enhancements Potential extensions to this project: -1. **Neo4j Integration**: Direct graph database storage for complex queries -2. **Machine Learning**: Predictive models for drug efficacy -3. **Temporal Analysis**: Track knowledge graph changes over time -4. **API Development**: REST API for programmatic access -5. **Cloud Deployment**: AWS/GCP hosting for web access -6. **Additional Data Sources**: Integrate DrugBank, KEGG, etc. +1. **Machine Learning**: Predictive models for drug efficacy +2. **Temporal Analysis**: Track knowledge graph changes over time +3. **API Development**: REST API for programmatic access +4. **Cloud Deployment**: AWS/GCP hosting for web access +5. **Additional Data Sources**: Integrate DrugBank, KEGG, etc. ## References diff --git a/dashboard_update.py b/dashboard.py similarity index 99% rename from dashboard_update.py rename to dashboard.py index efb845f..f2b7ce6 100644 --- a/dashboard_update.py +++ b/dashboard.py @@ -187,7 +187,7 @@ try: # HOTSPOT GENES PAGE elif page == "Hotspot Genes": - st.header("🧬 Hotspot Genes - Most Disease Associations") + st.header("Hotspot Genes - Most Disease Associations") col1, col2 = st.columns([3, 1]) @@ -347,7 +347,7 @@ try: ) perfect = super_drugs[(super_drugs['num_side_effects'] == 0) & (super_drugs['num_diseases_treated'] > 0)] - st.info(f"💎 Found {len(perfect)} drugs with ZERO documented side effects!") + st.info(f"Found {len(perfect)} drugs with ZERO documented side effects!") csv = filtered_super.to_csv(index=False).encode('utf-8') st.download_button("Download Super Drugs", csv, "super_drugs.csv", "text/csv") diff --git a/schnellerereETL.py b/etl.py similarity index 84% rename from schnellerereETL.py rename to etl.py index 61a8ed5..b2acb4a 100644 --- a/schnellerereETL.py +++ b/etl.py @@ -2,49 +2,6 @@ import json import pandas as pd from pathlib import Path from collections import defaultdict -from neo4j import GraphDatabase - -NEO4J_URI = "bolt://localhost:7687" -NEO4J_USER = "neo4j" -NEO4J_PASSWORD = "password" - -driver = GraphDatabase.driver( - NEO4J_URI, - auth=(NEO4J_USER, NEO4J_PASSWORD) -) - - - -def load_nodes(df, label): - with driver.session() as session: - for _, row in df.iterrows(): - session.run( - f""" - MERGE (n:{label} {{id: $id}}) - SET n += $props - """, - id=row["id"], - props=row.drop("id").dropna().to_dict() - ) - - -def load_edges(edges_df): - with driver.session() as session: - for _, row in edges_df.iterrows(): - session.run( - """ - MATCH (s {id: $source}) - MATCH (t {id: $target}) - CALL apoc.create.relationship(s, $type, {}, t) - YIELD rel - RETURN rel - """, - source=row["source"], - target=row["target"], - type=row["type"].upper() - ) - - # KONFIGURATION @@ -54,7 +11,7 @@ OUTPUT_DIR = Path("neo4j_csv") OUTPUT_DIR.mkdir(exist_ok=True) print("="*60) -print("HETIONET ETL PIPELINE") +print("HETIONET ETL PIPELINE (OPTIMIZED + SPLIT EDGES)") print("="*60) # EXTRACT @@ -74,7 +31,7 @@ print(f"Edges loaded: {len(edges_raw):,}") # TRANSFORM – NODES -print("\n PHASE 2: TRANSFORM NODES") +print("\nPHASE 2: TRANSFORM NODES") print("-"*60) nodes_flat = [] @@ -113,7 +70,7 @@ symptom_ids = set(nodes_df[nodes_df['kind'] == 'Symptom']['id']) compound_ids = set(nodes_df[nodes_df['kind'] == 'Compound']['id']) sideeffect_ids = set(nodes_df[nodes_df['kind'] == 'Side Effect']['id']) -print(f"\n Node Statistics:") +print(f"\nNode Statistics:") print(f" - Genes: {len(gene_ids):,}") print(f" - Diseases: {len(disease_ids):,}") print(f" - Symptoms: {len(symptom_ids):,}") @@ -121,7 +78,7 @@ print(f" - Compounds: {len(compound_ids):,}") print(f" - Side Effects: {len(sideeffect_ids):,}") # Export nodes by type -print("\n Exporting node files...") +print("\nExporting node files...") for kind in nodes_df["kind"].unique(): df_kind = ( nodes_df[nodes_df["kind"] == kind] @@ -153,29 +110,50 @@ edges_df = pd.DataFrame(edges) # Relationship-Typen Neo4j-sicher machen edges_df["type"] = edges_df["type"].str.replace(" ", "_").str.replace("-", "_") +# split edges into seperate files + +print("\nExporting edges by type to separate CSV files...") +print("-"*60) + +edge_types = edges_df['type'].unique() +for edge_type in sorted(edge_types): + edges_subset = edges_df[edges_df['type'] == edge_type] + filename = OUTPUT_DIR / f"edges_{edge_type}.csv" + + # Only export source and target (type is in filename) + edges_subset[['source', 'target']].to_csv(filename, index=False) + + size_mb = filename.stat().st_size / (1024*1024) + print(f" ✓ edges_{edge_type:20s}.csv ({len(edges_subset):>10,} rows, {size_mb:>6.2f} MB)") + +# Also keep the combined file for backward compatibility edges_file = OUTPUT_DIR / "edges_all.csv" edges_df.to_csv(edges_file, index=False) +print(f"\n ✓ edges_all.csv (combined) ({len(edges_df):,} rows)") -print(f"\n Edges processed: {len(edges_df):,}") -print(f"Saved to: {edges_file.name}") +print(f"\nSummary:") +print(f" Total edges: {len(edges_df):,}") +print(f" Split into {len(edge_types)} separate CSV files") +print(f" Each file can be loaded independently!") -# Pre-filter edges by type -print("\n Pre-filtering edges by type...") +# Pre-filter edges by type for analysis +print("\nEdge type distribution:") edges_by_type = {} -for edge_type in ['associates', 'treats', 'presents', 'causes', 'regulates', 'upregulates', 'downregulates', 'binds']: +for edge_type in sorted(edge_types): edges_by_type[edge_type] = edges_df[edges_df['type'] == edge_type].copy() - if len(edges_by_type[edge_type]) > 0: - print(f" - {edge_type}: {len(edges_by_type[edge_type]):,}") + count = len(edges_by_type[edge_type]) + pct = 100 * count / len(edges_df) + print(f" - {edge_type:20s}: {count:>10,} ({pct:>5.1f}%)") - -# ANALYSES +# [ANALYSES - keeping all the existing analysis code...] +# (Keeping the same analysis code as before) print("\n" + "="*60) print("PHASE 4: ANALYSES") print("="*60) # ANALYSIS 1: HOTSPOT GENES -print("\n Analysis 1: Hotspot Genes") +print("\nAnalysis 1: Hotspot Genes") print("-"*60) gene_disease_edges = pd.concat([ @@ -206,7 +184,7 @@ genes_df_sorted.to_csv(OUTPUT_DIR / "nodes_Gene.csv", index=False) print(f"Top gene: {genes_df_sorted.iloc[0]['name']} ({int(genes_df_sorted.iloc[0]['num_diseases'])} diseases)") # ANALYSIS 2: DISEASE SYMPTOM DIVERSITY -print("\n Analysis 2: Disease Symptom Diversity") +print("\nAnalysis 2: Disease Symptom Diversity") print("-"*60) disease_symptom_edges = edges_by_type.get('presents', pd.DataFrame()) @@ -231,7 +209,7 @@ disease_df_sorted.to_csv(OUTPUT_DIR / "nodes_Disease.csv", index=False) print(f"Top disease: {disease_df_sorted.iloc[0]['name']} ({int(disease_df_sorted.iloc[0]['num_symptoms'])} symptoms)") # Build indices for drug analyses -print("\n🔍 Building indices for drug analyses...") +print("\nBuilding indices for drug analyses...") disease_to_genes = defaultdict(set) gene_to_diseases = defaultdict(set) for _, row in gene_disease_edges.iterrows(): @@ -249,6 +227,17 @@ symptom_to_diseases = defaultdict(set) for _, row in disease_symptom_edges.iterrows(): symptom_to_diseases[row['target']].add(row['source']) +print("\nETL (Extract, Transform, Load CSV files) COMPLETED!") +print("="*60) +print("\n📁 Generated CSV files:") +print(f" - Node files: 5") +print(f" - Edge files (split): {len(edge_types)}") +print(f" - Edge file (combined): 1") +print(f" - Analysis files: Various") +print(f"\n💡 For faster Neo4j loading, use the split edge files:") +print(f" edges_associates.csv, edges_treats.csv, etc.") +print(f" Instead of the combined edges_all.csv") + # ANALYSIS 3: DRUG REPURPOSING print("\nAnalysis 3: Drug Repurposing Opportunities") print("-"*60) @@ -306,7 +295,7 @@ if len(drug_sideeffects) > 0: print(f"Analyzed {len(drug_risk_sorted):,} drugs for side effects") # ANALYSIS 5: SYMPTOM TRIANGLE -print("\n Analysis 5: Symptom-Disease-Drug Triangle") +print("\nAnalysis 5: Symptom-Disease-Drug Triangle") print("-"*60) drugs_with_sideeffects_set = set(drug_sideeffects['source']) if len(drug_sideeffects) > 0 else set() @@ -338,7 +327,7 @@ if len(symptom_triangle_df) > 0: print(f"Analyzed {len(symptom_triangle_df):,} symptoms") # ANALYSIS 6: SUPER DRUGS -print("\n Analysis 6: Super-Drug Score") +print("\nAnalysis 6: Super-Drug Score") print("-"*60) super_drugs = [] @@ -402,7 +391,7 @@ if len(drug_conflicts_df) > 0: print(f"Found {len(drug_conflicts_df):,} drug conflict pairs") # ANALYSIS 8: NETWORK DATA -print("\n🕸️ Analysis 8: Network Visualization Data") +print("\nAnalysis 8: Network Visualization Data") print("-"*60) top_diseases = disease_df_sorted.nlargest(20, 'num_symptoms')['id'].tolist() @@ -476,23 +465,8 @@ network_edges_df = pd.DataFrame(network_edges) network_nodes_df.to_csv(OUTPUT_DIR / "network_nodes.csv", index=False) network_edges_df.to_csv(OUTPUT_DIR / "network_edges.csv", index=False) - - -load_nodes(nodes_df[nodes_df['kind']=="Gene"], "Gene") -load_nodes(nodes_df[nodes_df['kind']=="Disease"], "Disease") -load_nodes(nodes_df[nodes_df['kind']=="Compound"], "Compound") -load_nodes(nodes_df[nodes_df['kind']=="Symptom"], "Symptom") -load_nodes(nodes_df[nodes_df['kind']=="Side Effect"], "SideEffect") - - -load_edges(edges_df) +print(f"Created network with {len(network_nodes_df):,} nodes and {len(network_edges_df):,} edges") -print(f"Network: {len(network_nodes_df)} nodes, {len(network_edges_df)} edges") - -print("\n" + "="*60) -print("ETL PIPELINE COMPLETED SUCCESSFULLY") -print("="*60) -print(f"\nOutput directory: {OUTPUT_DIR.resolve()}") diff --git a/neo4j_csv/analysis_drug_repurposing.csv b/neo4j_csv/analysis_drug_repurposing.csv index 707221f..d33b74e 100644 --- a/neo4j_csv/analysis_drug_repurposing.csv +++ b/neo4j_csv/analysis_drug_repurposing.csv @@ -1,972 +1,962 @@ disease,candidate_drug,shared_genes -hematologic cancer,Primidone,1007 -hematologic cancer,Valrubicin,1007 -hematologic cancer,Clopidogrel,1007 -hematologic cancer,Cyclosporine,1007 -hematologic cancer,Ticagrelor,1007 -hematologic cancer,Diltiazem,1007 -hematologic cancer,Bendroflumethiazide,1007 -hematologic cancer,Dipivefrin,1007 -hematologic cancer,Clobetasol propionate,1007 -hematologic cancer,Propylthiouracil,1007 -IgA glomerulonephritis,Melphalan,930 -IgA glomerulonephritis,Cyclosporine,930 -IgA glomerulonephritis,Teniposide,930 -IgA glomerulonephritis,Ticagrelor,930 -IgA glomerulonephritis,Dexamethasone,930 +IgA glomerulonephritis,Midazolam,930 +IgA glomerulonephritis,Ketotifen,930 +IgA glomerulonephritis,Anagrelide,930 +IgA glomerulonephritis,Oxcarbazepine,930 IgA glomerulonephritis,Valrubicin,930 -IgA glomerulonephritis,Bendroflumethiazide,930 -IgA glomerulonephritis,Dipivefrin,930 -IgA glomerulonephritis,Diltiazem,930 -IgA glomerulonephritis,Clopidogrel,930 -melanoma,Dipivefrin,828 -melanoma,Bendroflumethiazide,828 -melanoma,Valrubicin,828 -melanoma,Dexamethasone,828 -melanoma,Ticagrelor,828 -melanoma,Cyclosporine,828 -melanoma,Diltiazem,828 -melanoma,Melphalan,828 -melanoma,Teniposide,828 -melanoma,Clopidogrel,828 -schizophrenia,Valrubicin,729 -schizophrenia,Dipivefrin,729 -schizophrenia,Dexamethasone,729 -schizophrenia,Ticagrelor,729 -schizophrenia,Teniposide,729 -schizophrenia,Cyclosporine,729 -schizophrenia,Diltiazem,729 -schizophrenia,Clopidogrel,729 -schizophrenia,Melphalan,729 -schizophrenia,Bendroflumethiazide,729 -kidney cancer,Bendroflumethiazide,699 +IgA glomerulonephritis,Aminophylline,930 +IgA glomerulonephritis,Levetiracetam,930 +IgA glomerulonephritis,Primidone,930 +IgA glomerulonephritis,Propofol,930 +IgA glomerulonephritis,Benazepril,930 +rheumatoid arthritis,Valrubicin,741 +rheumatoid arthritis,Propofol,741 +rheumatoid arthritis,Primidone,741 +rheumatoid arthritis,Levetiracetam,741 +rheumatoid arthritis,Aminophylline,741 +rheumatoid arthritis,Benazepril,741 +rheumatoid arthritis,Oxcarbazepine,741 +rheumatoid arthritis,Anagrelide,741 +rheumatoid arthritis,Ketotifen,741 +rheumatoid arthritis,Midazolam,741 +kidney cancer,Benazepril,699 +kidney cancer,Midazolam,699 +kidney cancer,Propofol,699 +kidney cancer,Ketotifen,699 +kidney cancer,Anagrelide,699 +kidney cancer,Oxcarbazepine,699 kidney cancer,Valrubicin,699 -kidney cancer,Dexamethasone,699 -kidney cancer,Ticagrelor,699 -kidney cancer,Teniposide,699 -kidney cancer,Cyclosporine,699 -kidney cancer,Diltiazem,699 -kidney cancer,Melphalan,699 -kidney cancer,Dipivefrin,699 -kidney cancer,Clopidogrel,699 -polycystic ovary syndrome,Diltiazem,692 -polycystic ovary syndrome,Dipivefrin,692 -polycystic ovary syndrome,Bendroflumethiazide,692 -polycystic ovary syndrome,Valrubicin,692 -polycystic ovary syndrome,Dexamethasone,692 -polycystic ovary syndrome,Ticagrelor,692 -polycystic ovary syndrome,Teniposide,692 -polycystic ovary syndrome,Cyclosporine,692 -polycystic ovary syndrome,Clopidogrel,692 -polycystic ovary syndrome,Melphalan,692 -Alzheimer's disease,Cyclosporine,685 -Alzheimer's disease,Dexamethasone,685 -Alzheimer's disease,Ticagrelor,685 -Alzheimer's disease,Teniposide,685 +kidney cancer,Aminophylline,699 +kidney cancer,Levetiracetam,699 +kidney cancer,Primidone,699 +Alzheimer's disease,Anagrelide,685 +Alzheimer's disease,Aminophylline,685 Alzheimer's disease,Valrubicin,685 -Alzheimer's disease,Diltiazem,685 -Alzheimer's disease,Melphalan,685 -Alzheimer's disease,Dipivefrin,685 -Alzheimer's disease,Bendroflumethiazide,685 -Alzheimer's disease,Clopidogrel,685 -Parkinson's disease,Clopidogrel,637 -Parkinson's disease,Bendroflumethiazide,637 +Alzheimer's disease,Oxcarbazepine,685 +Alzheimer's disease,Propofol,685 +Alzheimer's disease,Ketotifen,685 +Alzheimer's disease,Midazolam,685 +Alzheimer's disease,Benazepril,685 +Alzheimer's disease,Primidone,685 +Alzheimer's disease,Levetiracetam,685 +Parkinson's disease,Levetiracetam,637 +Parkinson's disease,Aminophylline,637 +Parkinson's disease,Primidone,637 Parkinson's disease,Valrubicin,637 -Parkinson's disease,Dexamethasone,637 -Parkinson's disease,Ticagrelor,637 -Parkinson's disease,Teniposide,637 -Parkinson's disease,Cyclosporine,637 -Parkinson's disease,Diltiazem,637 -Parkinson's disease,Dipivefrin,637 -Parkinson's disease,Melphalan,637 +Parkinson's disease,Oxcarbazepine,637 +Parkinson's disease,Anagrelide,637 +Parkinson's disease,Ketotifen,637 +Parkinson's disease,Midazolam,637 +Parkinson's disease,Propofol,637 +Parkinson's disease,Benazepril,637 +lung cancer,Ketotifen,629 +lung cancer,Propofol,629 +lung cancer,Benazepril,629 +lung cancer,Anagrelide,629 +lung cancer,Oxcarbazepine,629 +lung cancer,Valrubicin,629 +lung cancer,Aminophylline,629 +lung cancer,Levetiracetam,629 +lung cancer,Primidone,629 +lung cancer,Midazolam,629 +pancreatic cancer,Propofol,628 +pancreatic cancer,Levetiracetam,628 pancreatic cancer,Valrubicin,628 -pancreatic cancer,Dipivefrin,628 -pancreatic cancer,Bendroflumethiazide,628 -pancreatic cancer,Cyclosporine,628 -pancreatic cancer,Dexamethasone,628 -pancreatic cancer,Ticagrelor,628 -pancreatic cancer,Teniposide,628 -pancreatic cancer,Melphalan,628 -pancreatic cancer,Clopidogrel,628 -pancreatic cancer,Diltiazem,628 -ulcerative colitis,Ticagrelor,611 -prostate cancer,Diltiazem,611 -Crohn's disease,Teniposide,611 -Crohn's disease,Ticagrelor,611 -Crohn's disease,Dexamethasone,611 +pancreatic cancer,Oxcarbazepine,628 +pancreatic cancer,Anagrelide,628 +pancreatic cancer,Ketotifen,628 +pancreatic cancer,Midazolam,628 +pancreatic cancer,Benazepril,628 +pancreatic cancer,Primidone,628 +pancreatic cancer,Aminophylline,628 +ulcerative colitis,Midazolam,611 +Crohn's disease,Primidone,611 +Crohn's disease,Aminophylline,611 Crohn's disease,Valrubicin,611 -Crohn's disease,Bendroflumethiazide,611 -Crohn's disease,Dipivefrin,611 -prostate cancer,Dipivefrin,611 -prostate cancer,Bendroflumethiazide,611 -ulcerative colitis,Melphalan,611 -prostate cancer,Melphalan,611 -prostate cancer,Clopidogrel,611 -prostate cancer,Cyclosporine,611 -ulcerative colitis,Teniposide,611 -prostate cancer,Teniposide,611 -prostate cancer,Ticagrelor,611 -prostate cancer,Dexamethasone,611 -prostate cancer,Valrubicin,611 -Crohn's disease,Melphalan,611 -Crohn's disease,Clopidogrel,611 -ulcerative colitis,Clobetasol propionate,611 -ulcerative colitis,Dipivefrin,611 -ulcerative colitis,Bendroflumethiazide,611 -ulcerative colitis,Diltiazem,611 -ulcerative colitis,Cyclosporine,611 -ulcerative colitis,Clopidogrel,611 +ulcerative colitis,Benazepril,611 +Crohn's disease,Oxcarbazepine,611 +Crohn's disease,Anagrelide,611 +Crohn's disease,Ketotifen,611 +Crohn's disease,Midazolam,611 +ulcerative colitis,Propofol,611 +Crohn's disease,Propofol,611 +ulcerative colitis,Primidone,611 +ulcerative colitis,Levetiracetam,611 +ulcerative colitis,Aminophylline,611 ulcerative colitis,Valrubicin,611 -Crohn's disease,Diltiazem,611 -Crohn's disease,Cyclosporine,611 -hypertension,Clobetasol propionate,596 -hypertension,Dipivefrin,596 +Crohn's disease,Benazepril,611 +ulcerative colitis,Anagrelide,611 +ulcerative colitis,Ketotifen,611 +ulcerative colitis,Oxcarbazepine,611 +Crohn's disease,Levetiracetam,611 +prostate cancer,Primidone,611 +prostate cancer,Levetiracetam,611 +prostate cancer,Valrubicin,611 +prostate cancer,Oxcarbazepine,611 +prostate cancer,Anagrelide,611 +prostate cancer,Ketotifen,611 +prostate cancer,Midazolam,611 +prostate cancer,Benazepril,611 +prostate cancer,Propofol,611 +prostate cancer,Aminophylline,611 +hypertension,Levetiracetam,596 +hypertension,Aminophylline,596 hypertension,Valrubicin,596 -hypertension,Dexamethasone,596 -hypertension,Ticagrelor,596 -hypertension,Teniposide,596 -hypertension,Cyclosporine,596 -hypertension,Clopidogrel,596 -hypertension,Melphalan,596 -hypertension,Propylthiouracil,596 -colon cancer,Melphalan,557 -colon cancer,Cyclosporine,557 -colon cancer,Teniposide,557 -colon cancer,Ticagrelor,557 -colon cancer,Bendroflumethiazide,557 -colon cancer,Dexamethasone,557 -colon cancer,Valrubicin,557 -colon cancer,Diltiazem,557 -colon cancer,Dipivefrin,557 -colon cancer,Clopidogrel,557 -amyotrophic lateral sclerosis,Ticagrelor,551 -amyotrophic lateral sclerosis,Diltiazem,551 -amyotrophic lateral sclerosis,Cyclosporine,551 -amyotrophic lateral sclerosis,Teniposide,551 +hypertension,Oxcarbazepine,596 +hypertension,Anagrelide,596 +hypertension,Ketotifen,596 +hypertension,Midazolam,596 +hypertension,Primidone,596 +hypertension,Pimecrolimus,596 +hypertension,Propofol,596 +psoriasis,Primidone,584 +psoriasis,Propofol,584 +psoriasis,Midazolam,584 +psoriasis,Ketotifen,584 +psoriasis,Anagrelide,584 +psoriasis,Oxcarbazepine,584 +psoriasis,Valrubicin,584 +psoriasis,Aminophylline,584 +psoriasis,Levetiracetam,584 +psoriasis,Benazepril,584 +chronic obstructive pulmonary disease,Oxcarbazepine,573 +chronic obstructive pulmonary disease,Primidone,573 +chronic obstructive pulmonary disease,Levetiracetam,573 +chronic obstructive pulmonary disease,Propofol,573 +chronic obstructive pulmonary disease,Anagrelide,573 +chronic obstructive pulmonary disease,Ketotifen,573 +chronic obstructive pulmonary disease,Midazolam,573 +chronic obstructive pulmonary disease,Benazepril,573 +chronic obstructive pulmonary disease,Valrubicin,573 +chronic obstructive pulmonary disease,Pimecrolimus,573 +amyotrophic lateral sclerosis,Oxcarbazepine,551 +amyotrophic lateral sclerosis,Midazolam,551 +amyotrophic lateral sclerosis,Propofol,551 +amyotrophic lateral sclerosis,Primidone,551 +amyotrophic lateral sclerosis,Levetiracetam,551 +amyotrophic lateral sclerosis,Aminophylline,551 amyotrophic lateral sclerosis,Valrubicin,551 -amyotrophic lateral sclerosis,Bendroflumethiazide,551 -amyotrophic lateral sclerosis,Dipivefrin,551 -amyotrophic lateral sclerosis,Dexamethasone,551 -amyotrophic lateral sclerosis,Clopidogrel,551 -amyotrophic lateral sclerosis,Melphalan,551 -systemic scleroderma,Melphalan,550 -systemic scleroderma,Valrubicin,550 -systemic scleroderma,Dipivefrin,550 -systemic scleroderma,Dexamethasone,550 -systemic scleroderma,Ticagrelor,550 -systemic scleroderma,Teniposide,550 -systemic scleroderma,Cyclosporine,550 -systemic scleroderma,Diltiazem,550 -systemic scleroderma,Clopidogrel,550 -systemic scleroderma,Bendroflumethiazide,550 -coronary artery disease,Clobetasol propionate,536 -coronary artery disease,Dipivefrin,536 -coronary artery disease,Bendroflumethiazide,536 +amyotrophic lateral sclerosis,Anagrelide,551 +amyotrophic lateral sclerosis,Ketotifen,551 +amyotrophic lateral sclerosis,Benazepril,551 +malaria,Midazolam,548 +malaria,Benazepril,548 +malaria,Propofol,548 +malaria,Anagrelide,548 +malaria,Oxcarbazepine,548 +malaria,Valrubicin,548 +malaria,Aminophylline,548 +malaria,Levetiracetam,548 +malaria,Primidone,548 +malaria,Ketotifen,548 +acquired immunodeficiency syndrome,Anagrelide,536 +acquired immunodeficiency syndrome,Benazepril,536 +acquired immunodeficiency syndrome,Midazolam,536 +acquired immunodeficiency syndrome,Ketotifen,536 +acquired immunodeficiency syndrome,Levetiracetam,536 +acquired immunodeficiency syndrome,Oxcarbazepine,536 +acquired immunodeficiency syndrome,Valrubicin,536 +acquired immunodeficiency syndrome,Aminophylline,536 +coronary artery disease,Benazepril,536 +acquired immunodeficiency syndrome,Propofol,536 +coronary artery disease,Propofol,536 +coronary artery disease,Primidone,536 +coronary artery disease,Levetiracetam,536 +coronary artery disease,Aminophylline,536 coronary artery disease,Valrubicin,536 -coronary artery disease,Dexamethasone,536 -coronary artery disease,Teniposide,536 -coronary artery disease,Cyclosporine,536 -coronary artery disease,Diltiazem,536 -coronary artery disease,Melphalan,536 -coronary artery disease,Propylthiouracil,536 -azoospermia,Clopidogrel,535 -azoospermia,Melphalan,535 -azoospermia,Dipivefrin,535 -azoospermia,Cyclosporine,535 +coronary artery disease,Oxcarbazepine,536 +coronary artery disease,Anagrelide,536 +coronary artery disease,Ketotifen,536 +coronary artery disease,Midazolam,536 +acquired immunodeficiency syndrome,Primidone,536 +azoospermia,Propofol,535 azoospermia,Valrubicin,535 -azoospermia,Dexamethasone,535 -azoospermia,Ticagrelor,535 -azoospermia,Teniposide,535 -azoospermia,Bendroflumethiazide,535 -azoospermia,Diltiazem,535 -Barrett's esophagus,Dipivefrin,523 -Barrett's esophagus,Bendroflumethiazide,523 +azoospermia,Primidone,535 +azoospermia,Levetiracetam,535 +azoospermia,Aminophylline,535 +azoospermia,Oxcarbazepine,535 +azoospermia,Anagrelide,535 +azoospermia,Ketotifen,535 +azoospermia,Midazolam,535 +azoospermia,Benazepril,535 +psoriatic arthritis,Primidone,523 +psoriatic arthritis,Propofol,523 +psoriatic arthritis,Midazolam,523 +psoriatic arthritis,Ketotifen,523 +psoriatic arthritis,Anagrelide,523 +psoriatic arthritis,Oxcarbazepine,523 +psoriatic arthritis,Valrubicin,523 +psoriatic arthritis,Aminophylline,523 +psoriatic arthritis,Levetiracetam,523 +psoriatic arthritis,Benazepril,523 +Barrett's esophagus,Propofol,523 +Barrett's esophagus,Anagrelide,523 +Barrett's esophagus,Benazepril,523 +Barrett's esophagus,Ketotifen,523 +Barrett's esophagus,Oxcarbazepine,523 Barrett's esophagus,Valrubicin,523 -Barrett's esophagus,Dexamethasone,523 -Barrett's esophagus,Ticagrelor,523 -Barrett's esophagus,Melphalan,523 -Barrett's esophagus,Cyclosporine,523 -Barrett's esophagus,Diltiazem,523 -Barrett's esophagus,Teniposide,523 -Barrett's esophagus,Clopidogrel,523 -abdominal aortic aneurysm,Melphalan,522 -abdominal aortic aneurysm,Clopidogrel,522 -abdominal aortic aneurysm,Diltiazem,522 -abdominal aortic aneurysm,Cyclosporine,522 -abdominal aortic aneurysm,Teniposide,522 -abdominal aortic aneurysm,Ticagrelor,522 -abdominal aortic aneurysm,Dexamethasone,522 +Barrett's esophagus,Aminophylline,523 +Barrett's esophagus,Levetiracetam,523 +Barrett's esophagus,Primidone,523 +Barrett's esophagus,Midazolam,523 +abdominal aortic aneurysm,Propofol,522 +abdominal aortic aneurysm,Levetiracetam,522 +abdominal aortic aneurysm,Aminophylline,522 abdominal aortic aneurysm,Valrubicin,522 -abdominal aortic aneurysm,Bendroflumethiazide,522 -abdominal aortic aneurysm,Dipivefrin,522 -nicotine dependence,Cyclosporine,519 -nicotine dependence,Melphalan,519 -nicotine dependence,Clopidogrel,519 -nicotine dependence,Diltiazem,519 -nicotine dependence,Dexamethasone,519 -nicotine dependence,Teniposide,519 -nicotine dependence,Ticagrelor,519 -nicotine dependence,Valrubicin,519 -nicotine dependence,Bendroflumethiazide,519 -nicotine dependence,Dipivefrin,519 -idiopathic pulmonary fibrosis,Dipivefrin,518 -idiopathic pulmonary fibrosis,Bendroflumethiazide,518 +abdominal aortic aneurysm,Oxcarbazepine,522 +abdominal aortic aneurysm,Anagrelide,522 +abdominal aortic aneurysm,Ketotifen,522 +abdominal aortic aneurysm,Primidone,522 +abdominal aortic aneurysm,Midazolam,522 +abdominal aortic aneurysm,Benazepril,522 +idiopathic pulmonary fibrosis,Midazolam,518 +idiopathic pulmonary fibrosis,Ketotifen,518 +idiopathic pulmonary fibrosis,Anagrelide,518 +idiopathic pulmonary fibrosis,Propofol,518 +idiopathic pulmonary fibrosis,Oxcarbazepine,518 idiopathic pulmonary fibrosis,Valrubicin,518 -idiopathic pulmonary fibrosis,Dexamethasone,518 -idiopathic pulmonary fibrosis,Cyclosporine,518 -idiopathic pulmonary fibrosis,Diltiazem,518 -idiopathic pulmonary fibrosis,Clopidogrel,518 -idiopathic pulmonary fibrosis,Melphalan,518 -idiopathic pulmonary fibrosis,Ticagrelor,518 -idiopathic pulmonary fibrosis,Teniposide,518 -alopecia areata,Diltiazem,510 -alopecia areata,Clopidogrel,510 -alopecia areata,Dipivefrin,510 -alopecia areata,Bendroflumethiazide,510 +idiopathic pulmonary fibrosis,Aminophylline,518 +idiopathic pulmonary fibrosis,Benazepril,518 +idiopathic pulmonary fibrosis,Levetiracetam,518 +idiopathic pulmonary fibrosis,Primidone,518 +alopecia areata,Primidone,510 +alopecia areata,Oxcarbazepine,510 +alopecia areata,Levetiracetam,510 +alopecia areata,Aminophylline,510 alopecia areata,Valrubicin,510 -alopecia areata,Dexamethasone,510 -alopecia areata,Ticagrelor,510 -alopecia areata,Teniposide,510 -alopecia areata,Cyclosporine,510 -alopecia areata,Melphalan,510 -uterine fibroid,Ticagrelor,403 -uterine fibroid,Diltiazem,403 -uterine fibroid,Cyclosporine,403 -uterine fibroid,Teniposide,403 -uterine fibroid,Clopidogrel,403 -uterine fibroid,Dexamethasone,403 +alopecia areata,Ketotifen,510 +alopecia areata,Anagrelide,510 +alopecia areata,Midazolam,510 +alopecia areata,Benazepril,510 +alopecia areata,Propofol,510 +obesity,Primidone,485 +obesity,Valrubicin,485 +obesity,Levetiracetam,485 +obesity,Benazepril,485 +obesity,Midazolam,485 +obesity,Ketotifen,485 +obesity,Anagrelide,485 +obesity,Oxcarbazepine,485 +obesity,Aminophylline,485 +obesity,Propofol,485 +uterine fibroid,Aminophylline,403 +uterine fibroid,Oxcarbazepine,403 +uterine fibroid,Benazepril,403 +uterine fibroid,Ketotifen,403 +uterine fibroid,Anagrelide,403 +uterine fibroid,Midazolam,403 uterine fibroid,Valrubicin,403 -uterine fibroid,Bendroflumethiazide,403 -uterine fibroid,Melphalan,403 -uterine fibroid,Dipivefrin,403 -alcohol dependence,Clopidogrel,353 -alcohol dependence,Melphalan,353 -alcohol dependence,Bendroflumethiazide,353 -alcohol dependence,Valrubicin,353 -alcohol dependence,Diltiazem,353 -alcohol dependence,Cyclosporine,353 -alcohol dependence,Teniposide,353 -alcohol dependence,Ticagrelor,353 -alcohol dependence,Dexamethasone,353 -alcohol dependence,Dipivefrin,353 -stomach cancer,Melphalan,298 -stomach cancer,Bendroflumethiazide,298 +uterine fibroid,Levetiracetam,403 +uterine fibroid,Primidone,403 +uterine fibroid,Propofol,403 +epilepsy syndrome,Benazepril,399 +epilepsy syndrome,Dactinomycin,399 +epilepsy syndrome,WF10,399 +epilepsy syndrome,Nilutamide,399 +epilepsy syndrome,Methylprednisolone,399 +epilepsy syndrome,Pimecrolimus,399 +epilepsy syndrome,Aminophylline,399 +epilepsy syndrome,Valrubicin,399 +epilepsy syndrome,Ketotifen,399 +epilepsy syndrome,Anagrelide,399 +ovarian cancer,Oxcarbazepine,317 +ovarian cancer,Propofol,317 +ovarian cancer,Benazepril,317 +ovarian cancer,Midazolam,317 +ovarian cancer,Ketotifen,317 +ovarian cancer,Anagrelide,317 +ovarian cancer,Valrubicin,317 +ovarian cancer,Aminophylline,317 +ovarian cancer,Levetiracetam,317 +ovarian cancer,Primidone,317 +stomach cancer,Benazepril,298 +stomach cancer,Levetiracetam,298 +stomach cancer,Primidone,298 +stomach cancer,Midazolam,298 +stomach cancer,Propofol,298 +stomach cancer,Aminophylline,298 stomach cancer,Valrubicin,298 -stomach cancer,Clopidogrel,298 -stomach cancer,Diltiazem,298 -stomach cancer,Cyclosporine,298 -stomach cancer,Teniposide,298 -stomach cancer,Dipivefrin,298 -stomach cancer,Ticagrelor,298 -stomach cancer,Dexamethasone,298 -type 2 diabetes mellitus,Clopidogrel,276 -type 2 diabetes mellitus,Diltiazem,276 -type 2 diabetes mellitus,Teniposide,276 -type 2 diabetes mellitus,Melphalan,276 -type 2 diabetes mellitus,Cyclosporine,276 -type 2 diabetes mellitus,Dipivefrin,276 -type 2 diabetes mellitus,Ticagrelor,276 -type 2 diabetes mellitus,Valrubicin,276 -type 2 diabetes mellitus,Bendroflumethiazide,276 -type 2 diabetes mellitus,Dexamethasone,276 -anemia,Dipivefrin,262 -anemia,Melphalan,262 -anemia,Diltiazem,262 -anemia,Cyclosporine,262 -anemia,Teniposide,262 -anemia,Ticagrelor,262 -anemia,Dexamethasone,262 -anemia,Bendroflumethiazide,262 -anemia,Valrubicin,262 -anemia,Clopidogrel,262 -autistic disorder,Dexamethasone,257 -autistic disorder,Dipivefrin,257 -autistic disorder,Clopidogrel,257 -autistic disorder,Bendroflumethiazide,257 +stomach cancer,Oxcarbazepine,298 +stomach cancer,Anagrelide,298 +stomach cancer,Ketotifen,298 +autistic disorder,Midazolam,257 +autistic disorder,Benazepril,257 +autistic disorder,Propofol,257 +autistic disorder,Ketotifen,257 +autistic disorder,Anagrelide,257 +autistic disorder,Oxcarbazepine,257 autistic disorder,Valrubicin,257 -autistic disorder,Melphalan,257 -autistic disorder,Ticagrelor,257 -autistic disorder,Teniposide,257 -autistic disorder,Cyclosporine,257 -autistic disorder,Diltiazem,257 -ankylosing spondylitis,Bendroflumethiazide,182 -ankylosing spondylitis,Valrubicin,182 -ankylosing spondylitis,Ticagrelor,182 -ankylosing spondylitis,Teniposide,182 -ankylosing spondylitis,Clobetasol propionate,182 -ankylosing spondylitis,Cyclosporine,182 -ankylosing spondylitis,Diltiazem,182 -ankylosing spondylitis,Clopidogrel,182 -ankylosing spondylitis,Melphalan,182 -ankylosing spondylitis,Dipivefrin,182 -malignant glioma,Ticagrelor,181 -malignant glioma,Dipivefrin,181 +autistic disorder,Aminophylline,257 +autistic disorder,Levetiracetam,257 +autistic disorder,Primidone,257 +asthma,Levetiracetam,226 +asthma,Pimecrolimus,226 +asthma,Propofol,226 +asthma,Primidone,226 +asthma,Midazolam,226 +asthma,Valrubicin,226 +asthma,Oxcarbazepine,226 +asthma,Anagrelide,226 +asthma,Benazepril,226 +asthma,Nilutamide,226 +malignant glioma,Oxcarbazepine,181 +malignant glioma,Benazepril,181 +malignant glioma,Propofol,181 +malignant glioma,Primidone,181 +malignant glioma,Levetiracetam,181 +malignant glioma,Aminophylline,181 +malignant glioma,Midazolam,181 +malignant glioma,Ketotifen,181 +malignant glioma,Anagrelide,181 malignant glioma,Valrubicin,181 -malignant glioma,Dexamethasone,181 -malignant glioma,Teniposide,181 -malignant glioma,Cyclosporine,181 -malignant glioma,Diltiazem,181 -malignant glioma,Clopidogrel,181 -malignant glioma,Bendroflumethiazide,181 -malignant glioma,Melphalan,181 -liver cancer,Teniposide,179 -liver cancer,Melphalan,179 -liver cancer,Clopidogrel,179 -liver cancer,Diltiazem,179 -liver cancer,Cyclosporine,179 -liver cancer,Dexamethasone,179 -liver cancer,Ticagrelor,179 +liver cancer,Propofol,179 +liver cancer,Midazolam,179 +liver cancer,Aminophylline,179 +liver cancer,Ketotifen,179 +liver cancer,Primidone,179 +liver cancer,Levetiracetam,179 +liver cancer,Benazepril,179 liver cancer,Valrubicin,179 -liver cancer,Bendroflumethiazide,179 -liver cancer,Dipivefrin,179 -atherosclerosis,Dexamethasone,166 -atherosclerosis,Melphalan,166 -atherosclerosis,Clopidogrel,166 -atherosclerosis,Cyclosporine,166 -atherosclerosis,Teniposide,166 -atherosclerosis,Ticagrelor,166 -atherosclerosis,Diltiazem,166 -atherosclerosis,Dipivefrin,166 -atherosclerosis,Bendroflumethiazide,166 -atherosclerosis,Valrubicin,166 -multiple sclerosis,Diltiazem,165 -multiple sclerosis,Melphalan,165 -multiple sclerosis,Clobetasol propionate,165 -multiple sclerosis,Clopidogrel,165 -multiple sclerosis,Dipivefrin,165 -multiple sclerosis,Cyclosporine,165 -multiple sclerosis,Teniposide,165 -multiple sclerosis,Ticagrelor,165 +liver cancer,Anagrelide,179 +liver cancer,Oxcarbazepine,179 +multiple sclerosis,Propofol,165 +multiple sclerosis,Primidone,165 +multiple sclerosis,Benazepril,165 +multiple sclerosis,Midazolam,165 +multiple sclerosis,Ketotifen,165 +multiple sclerosis,Anagrelide,165 +multiple sclerosis,Oxcarbazepine,165 multiple sclerosis,Valrubicin,165 -multiple sclerosis,Bendroflumethiazide,165 -systemic lupus erythematosus,Clopidogrel,155 -systemic lupus erythematosus,Diltiazem,155 -systemic lupus erythematosus,Teniposide,155 -systemic lupus erythematosus,Ticagrelor,155 +multiple sclerosis,Aminophylline,165 +multiple sclerosis,Levetiracetam,165 +systemic lupus erythematosus,Primidone,155 +systemic lupus erythematosus,Propofol,155 +systemic lupus erythematosus,Levetiracetam,155 +systemic lupus erythematosus,Aminophylline,155 +systemic lupus erythematosus,Oxcarbazepine,155 +systemic lupus erythematosus,Anagrelide,155 +systemic lupus erythematosus,Ketotifen,155 +systemic lupus erythematosus,Midazolam,155 +systemic lupus erythematosus,Benazepril,155 systemic lupus erythematosus,Valrubicin,155 -systemic lupus erythematosus,Bendroflumethiazide,155 -systemic lupus erythematosus,Dipivefrin,155 -systemic lupus erythematosus,Propylthiouracil,155 -systemic lupus erythematosus,Clobetasol propionate,155 -systemic lupus erythematosus,Melphalan,155 -type 1 diabetes mellitus,Teniposide,148 -type 1 diabetes mellitus,Dipivefrin,148 -type 1 diabetes mellitus,Diltiazem,148 -type 1 diabetes mellitus,Clopidogrel,148 -type 1 diabetes mellitus,Ticagrelor,148 -type 1 diabetes mellitus,Dexamethasone,148 -type 1 diabetes mellitus,Cyclosporine,148 -type 1 diabetes mellitus,Valrubicin,148 -type 1 diabetes mellitus,Melphalan,148 -type 1 diabetes mellitus,Bendroflumethiazide,148 -glaucoma,Cyclosporine,122 -glaucoma,Clobetasol propionate,122 -glaucoma,Diltiazem,122 -glaucoma,Bendroflumethiazide,122 -glaucoma,Dexamethasone,122 -glaucoma,Teniposide,122 -glaucoma,Melphalan,122 -glaucoma,Clopidogrel,122 +chronic kidney failure,Benazepril,132 +chronic kidney failure,Aminophylline,132 +chronic kidney failure,Ketotifen,132 +chronic kidney failure,Midazolam,132 +chronic kidney failure,Propofol,132 +chronic kidney failure,Primidone,132 +chronic kidney failure,Levetiracetam,132 +chronic kidney failure,Valrubicin,132 +chronic kidney failure,Oxcarbazepine,132 +chronic kidney failure,Anagrelide,132 +glaucoma,Midazolam,122 +glaucoma,Benazepril,122 +glaucoma,Propofol,122 glaucoma,Valrubicin,122 -glaucoma,Ticagrelor,122 -salivary gland cancer,Dipivefrin,118 -salivary gland cancer,Bendroflumethiazide,118 +glaucoma,Ketotifen,122 +glaucoma,Primidone,122 +glaucoma,Oxcarbazepine,122 +glaucoma,Anagrelide,122 +glaucoma,Aminophylline,122 +glaucoma,Levetiracetam,122 +urinary bladder cancer,Benazepril,121 +urinary bladder cancer,Midazolam,121 +urinary bladder cancer,Pimecrolimus,121 +urinary bladder cancer,Ketotifen,121 +urinary bladder cancer,Anagrelide,121 +urinary bladder cancer,Oxcarbazepine,121 +urinary bladder cancer,Aminophylline,121 +urinary bladder cancer,Levetiracetam,121 +urinary bladder cancer,Primidone,121 +urinary bladder cancer,Propofol,121 +salivary gland cancer,Anagrelide,118 +salivary gland cancer,Propofol,118 +salivary gland cancer,Ketotifen,118 +salivary gland cancer,Primidone,118 +salivary gland cancer,Benazepril,118 +salivary gland cancer,Midazolam,118 +salivary gland cancer,Oxcarbazepine,118 salivary gland cancer,Valrubicin,118 -salivary gland cancer,Dexamethasone,118 -salivary gland cancer,Ticagrelor,118 -salivary gland cancer,Teniposide,118 -salivary gland cancer,Cyclosporine,118 -salivary gland cancer,Diltiazem,118 -salivary gland cancer,Clopidogrel,118 -salivary gland cancer,Melphalan,118 -bipolar disorder,Clopidogrel,106 -bipolar disorder,Melphalan,106 -bipolar disorder,Diltiazem,106 -bipolar disorder,Teniposide,106 -bipolar disorder,Ticagrelor,106 -bipolar disorder,Dexamethasone,106 +salivary gland cancer,Aminophylline,118 +salivary gland cancer,Levetiracetam,118 +bipolar disorder,Benazepril,106 +bipolar disorder,Ketotifen,106 +bipolar disorder,Anagrelide,106 +bipolar disorder,Oxcarbazepine,106 bipolar disorder,Valrubicin,106 -bipolar disorder,Bendroflumethiazide,106 -bipolar disorder,Dipivefrin,106 -bipolar disorder,Cyclosporine,106 -osteoporosis,Teniposide,98 -osteoporosis,Melphalan,98 -osteoporosis,Dipivefrin,98 -osteoporosis,Bendroflumethiazide,98 +bipolar disorder,Aminophylline,106 +bipolar disorder,Levetiracetam,106 +bipolar disorder,Primidone,106 +bipolar disorder,Propofol,106 +bipolar disorder,Midazolam,106 +pancreatitis,Oxcarbazepine,103 +pancreatitis,Primidone,103 +pancreatitis,Propofol,103 +pancreatitis,Levetiracetam,103 +pancreatitis,Aminophylline,103 +pancreatitis,Valrubicin,103 +pancreatitis,Anagrelide,103 +pancreatitis,Ketotifen,103 +pancreatitis,Midazolam,103 +pancreatitis,Benazepril,103 +osteoporosis,Primidone,98 +refractive error,Propofol,98 +osteoporosis,Propofol,98 +osteoporosis,Benazepril,98 +osteoporosis,Midazolam,98 +osteoporosis,Ketotifen,98 +osteoporosis,Anagrelide,98 +osteoporosis,Oxcarbazepine,98 osteoporosis,Valrubicin,98 -osteoporosis,Ticagrelor,98 -osteoporosis,Clopidogrel,98 -refractive error,Dipivefrin,98 -osteoporosis,Diltiazem,98 -refractive error,Melphalan,98 -refractive error,Clopidogrel,98 -refractive error,Bendroflumethiazide,98 -refractive error,Teniposide,98 -refractive error,Diltiazem,98 -osteoporosis,Cyclosporine,98 -refractive error,Cyclosporine,98 -refractive error,Ticagrelor,98 -refractive error,Dexamethasone,98 +osteoporosis,Aminophylline,98 +refractive error,Primidone,98 +osteoporosis,Levetiracetam,98 +refractive error,Midazolam,98 +refractive error,Levetiracetam,98 +refractive error,Aminophylline,98 refractive error,Valrubicin,98 -osteoporosis,Dexamethasone,98 -metabolic syndrome X,Melphalan,90 -metabolic syndrome X,Clopidogrel,90 -metabolic syndrome X,Diltiazem,90 -metabolic syndrome X,Cyclosporine,90 -metabolic syndrome X,Teniposide,90 -metabolic syndrome X,Dexamethasone,90 -metabolic syndrome X,Ticagrelor,90 -metabolic syndrome X,Dipivefrin,90 -metabolic syndrome X,Bendroflumethiazide,90 +refractive error,Oxcarbazepine,98 +refractive error,Anagrelide,98 +refractive error,Ketotifen,98 +refractive error,Benazepril,98 +metabolic syndrome X,Oxcarbazepine,90 +metabolic syndrome X,Midazolam,90 +metabolic syndrome X,Ketotifen,90 +metabolic syndrome X,Anagrelide,90 +metabolic syndrome X,Benazepril,90 metabolic syndrome X,Valrubicin,90 -uterine cancer,Ticagrelor,89 -uterine cancer,Bendroflumethiazide,89 +metabolic syndrome X,Aminophylline,90 +metabolic syndrome X,Levetiracetam,90 +metabolic syndrome X,Propofol,90 +metabolic syndrome X,Primidone,90 +uterine cancer,Anagrelide,89 +uterine cancer,Propofol,89 +uterine cancer,Primidone,89 +uterine cancer,Levetiracetam,89 +uterine cancer,Aminophylline,89 uterine cancer,Valrubicin,89 -uterine cancer,Dipivefrin,89 -uterine cancer,Melphalan,89 -uterine cancer,Clopidogrel,89 -uterine cancer,Diltiazem,89 -uterine cancer,Cyclosporine,89 -uterine cancer,Teniposide,89 -uterine cancer,Dexamethasone,89 +uterine cancer,Oxcarbazepine,89 +uterine cancer,Ketotifen,89 +uterine cancer,Midazolam,89 +uterine cancer,Benazepril,89 +primary biliary cirrhosis,Benazepril,78 primary biliary cirrhosis,Valrubicin,78 -primary biliary cirrhosis,Clopidogrel,78 -primary biliary cirrhosis,Dexamethasone,78 -primary biliary cirrhosis,Melphalan,78 -primary biliary cirrhosis,Bendroflumethiazide,78 -primary biliary cirrhosis,Dipivefrin,78 -primary biliary cirrhosis,Ticagrelor,78 -primary biliary cirrhosis,Teniposide,78 -primary biliary cirrhosis,Cyclosporine,78 -primary biliary cirrhosis,Diltiazem,78 -atopic dermatitis,Bendroflumethiazide,77 -atopic dermatitis,Cyclosporine,77 -atopic dermatitis,Diltiazem,77 -atopic dermatitis,Teniposide,77 -atopic dermatitis,Ticagrelor,77 -atopic dermatitis,Valrubicin,77 -atopic dermatitis,Melphalan,77 -atopic dermatitis,Dipivefrin,77 -atopic dermatitis,Clobetasol propionate,77 -atopic dermatitis,Clopidogrel,77 -bone cancer,Melphalan,74 -bone cancer,Clopidogrel,74 -bone cancer,Diltiazem,74 -bone cancer,Teniposide,74 -bone cancer,Ticagrelor,74 -bone cancer,Dexamethasone,74 -bone cancer,Valrubicin,74 -bone cancer,Bendroflumethiazide,74 -bone cancer,Dipivefrin,74 -bone cancer,Cyclosporine,74 -dilated cardiomyopathy,Dipivefrin,72 -dilated cardiomyopathy,Melphalan,72 -dilated cardiomyopathy,Bendroflumethiazide,72 -dilated cardiomyopathy,Teniposide,72 -dilated cardiomyopathy,Diltiazem,72 -dilated cardiomyopathy,Cyclosporine,72 -dilated cardiomyopathy,Clopidogrel,72 -dilated cardiomyopathy,Ticagrelor,72 -dilated cardiomyopathy,Dexamethasone,72 +primary biliary cirrhosis,Midazolam,78 +primary biliary cirrhosis,Aminophylline,78 +primary biliary cirrhosis,Ketotifen,78 +primary biliary cirrhosis,Primidone,78 +primary biliary cirrhosis,Levetiracetam,78 +primary biliary cirrhosis,Propofol,78 +primary biliary cirrhosis,Oxcarbazepine,78 +primary biliary cirrhosis,Anagrelide,78 +dilated cardiomyopathy,Levetiracetam,72 +dilated cardiomyopathy,Primidone,72 +dilated cardiomyopathy,Aminophylline,72 dilated cardiomyopathy,Valrubicin,72 -skin cancer,Melphalan,69 -skin cancer,Clopidogrel,69 -skin cancer,Diltiazem,69 -sarcoma,Bendroflumethiazide,69 -skin cancer,Cyclosporine,69 -skin cancer,Teniposide,69 -skin cancer,Ticagrelor,69 -skin cancer,Dexamethasone,69 +dilated cardiomyopathy,Oxcarbazepine,72 +dilated cardiomyopathy,Anagrelide,72 +dilated cardiomyopathy,Ketotifen,72 +dilated cardiomyopathy,Midazolam,72 +dilated cardiomyopathy,Benazepril,72 +dilated cardiomyopathy,Propofol,72 +peripheral nervous system neoplasm,Levetiracetam,70 +peripheral nervous system neoplasm,Primidone,70 +peripheral nervous system neoplasm,Propofol,70 +peripheral nervous system neoplasm,Aminophylline,70 +peripheral nervous system neoplasm,Valrubicin,70 +peripheral nervous system neoplasm,Oxcarbazepine,70 +peripheral nervous system neoplasm,Anagrelide,70 +peripheral nervous system neoplasm,Ketotifen,70 +peripheral nervous system neoplasm,Benazepril,70 +peripheral nervous system neoplasm,Midazolam,70 +sarcoma,Midazolam,69 +skin cancer,Oxcarbazepine,69 skin cancer,Valrubicin,69 -skin cancer,Bendroflumethiazide,69 -skin cancer,Dipivefrin,69 -sarcoma,Dipivefrin,69 -sarcoma,Dexamethasone,69 +skin cancer,Aminophylline,69 +skin cancer,Levetiracetam,69 +skin cancer,Primidone,69 +sarcoma,Benazepril,69 sarcoma,Valrubicin,69 -sarcoma,Teniposide,69 -sarcoma,Cyclosporine,69 -sarcoma,Diltiazem,69 -sarcoma,Clopidogrel,69 -sarcoma,Melphalan,69 -sarcoma,Ticagrelor,69 -hepatitis B,Dipivefrin,68 -hepatitis B,Dexamethasone,68 +sarcoma,Ketotifen,69 +sarcoma,Anagrelide,69 +skin cancer,Ketotifen,69 +sarcoma,Aminophylline,69 +sarcoma,Levetiracetam,69 +sarcoma,Primidone,69 +sarcoma,Propofol,69 +skin cancer,Propofol,69 +skin cancer,Anagrelide,69 +sarcoma,Oxcarbazepine,69 +skin cancer,Midazolam,69 +skin cancer,Benazepril,69 +hepatitis B,Benazepril,68 +hepatitis B,Midazolam,68 +hepatitis B,Levetiracetam,68 +hepatitis B,Primidone,68 +hepatitis B,Propofol,68 +hepatitis B,Ketotifen,68 +hepatitis B,Anagrelide,68 +hepatitis B,Oxcarbazepine,68 hepatitis B,Valrubicin,68 -hepatitis B,Bendroflumethiazide,68 -hepatitis B,Ticagrelor,68 -hepatitis B,Diltiazem,68 -hepatitis B,Clopidogrel,68 -hepatitis B,Melphalan,68 -hepatitis B,Cyclosporine,68 -hepatitis B,Teniposide,68 -osteoarthritis,Dipivefrin,62 -osteoarthritis,Bendroflumethiazide,62 +hepatitis B,Aminophylline,68 +osteoarthritis,Benazepril,62 +osteoarthritis,Propofol,62 +osteoarthritis,Primidone,62 +osteoarthritis,Levetiracetam,62 +osteoarthritis,Aminophylline,62 +osteoarthritis,Ketotifen,62 +osteoarthritis,Anagrelide,62 +osteoarthritis,Oxcarbazepine,62 osteoarthritis,Valrubicin,62 -osteoarthritis,Dexamethasone,62 -osteoarthritis,Ticagrelor,62 -osteoarthritis,Teniposide,62 -osteoarthritis,Cyclosporine,62 -osteoarthritis,Diltiazem,62 -osteoarthritis,Clopidogrel,62 -osteoarthritis,Melphalan,62 -germ cell cancer,Clopidogrel,58 -thyroid cancer,Cyclosporine,58 -germ cell cancer,Valrubicin,58 -germ cell cancer,Bendroflumethiazide,58 -germ cell cancer,Dipivefrin,58 -thyroid cancer,Clopidogrel,58 -thyroid cancer,Diltiazem,58 -thyroid cancer,Bendroflumethiazide,58 -thyroid cancer,Teniposide,58 -thyroid cancer,Ticagrelor,58 -thyroid cancer,Dexamethasone,58 +osteoarthritis,Midazolam,62 +thyroid cancer,Propofol,58 +thyroid cancer,Levetiracetam,58 +germ cell cancer,Levetiracetam,58 +thyroid cancer,Aminophylline,58 thyroid cancer,Valrubicin,58 -germ cell cancer,Ticagrelor,58 -thyroid cancer,Dipivefrin,58 -germ cell cancer,Dexamethasone,58 -thyroid cancer,Melphalan,58 -germ cell cancer,Cyclosporine,58 -germ cell cancer,Diltiazem,58 -germ cell cancer,Melphalan,58 -germ cell cancer,Teniposide,58 -head and neck cancer,Melphalan,55 +thyroid cancer,Oxcarbazepine,58 +thyroid cancer,Anagrelide,58 +thyroid cancer,Ketotifen,58 +thyroid cancer,Midazolam,58 +thyroid cancer,Benazepril,58 +germ cell cancer,Aminophylline,58 +germ cell cancer,Midazolam,58 +germ cell cancer,Anagrelide,58 +germ cell cancer,Methylprednisolone,58 +thyroid cancer,Primidone,58 +germ cell cancer,Valrubicin,58 +germ cell cancer,Benazepril,58 +germ cell cancer,Oxcarbazepine,58 +germ cell cancer,Propofol,58 +germ cell cancer,Primidone,58 +age related macular degeneration,Benazepril,55 +age related macular degeneration,Midazolam,55 +age related macular degeneration,Ketotifen,55 +age related macular degeneration,Anagrelide,55 +age related macular degeneration,Oxcarbazepine,55 +age related macular degeneration,Aminophylline,55 +age related macular degeneration,Levetiracetam,55 +age related macular degeneration,Primidone,55 +age related macular degeneration,Propofol,55 +age related macular degeneration,Methylprednisolone,55 +head and neck cancer,Ketotifen,55 +head and neck cancer,Benazepril,55 +head and neck cancer,Midazolam,55 +head and neck cancer,Anagrelide,55 +head and neck cancer,Oxcarbazepine,55 head and neck cancer,Valrubicin,55 -head and neck cancer,Dexamethasone,55 -head and neck cancer,Ticagrelor,55 -head and neck cancer,Teniposide,55 -head and neck cancer,Cyclosporine,55 -head and neck cancer,Diltiazem,55 -head and neck cancer,Clopidogrel,55 -head and neck cancer,Bendroflumethiazide,55 -head and neck cancer,Dipivefrin,55 -migraine,Clopidogrel,46 -migraine,Teniposide,46 -migraine,Dipivefrin,46 -migraine,Bendroflumethiazide,46 +head and neck cancer,Aminophylline,55 +head and neck cancer,Levetiracetam,55 +head and neck cancer,Primidone,55 +head and neck cancer,Propofol,55 +cleft lip,Midazolam,54 +cleft lip,Benazepril,54 +ocular cancer,Propofol,54 +cleft lip,Ketotifen,54 +ocular cancer,Valrubicin,54 +cleft lip,Propofol,54 +cleft lip,Primidone,54 +cleft lip,Levetiracetam,54 +cleft lip,Aminophylline,54 +ocular cancer,Primidone,54 +ocular cancer,Levetiracetam,54 +ocular cancer,Aminophylline,54 +ocular cancer,Oxcarbazepine,54 +ocular cancer,Benazepril,54 +cleft lip,Anagrelide,54 +ocular cancer,Anagrelide,54 +ocular cancer,Ketotifen,54 +ocular cancer,Midazolam,54 +cleft lip,Valrubicin,54 +cleft lip,Oxcarbazepine,54 +celiac disease,Oxcarbazepine,48 +celiac disease,Anagrelide,48 +celiac disease,Ketotifen,48 +celiac disease,Midazolam,48 +celiac disease,Benazepril,48 +celiac disease,Primidone,48 +celiac disease,Propofol,48 +celiac disease,Pimecrolimus,48 +celiac disease,Levetiracetam,48 +celiac disease,Aminophylline,48 +migraine,Ketotifen,46 +migraine,Benazepril,46 +migraine,Levetiracetam,46 +migraine,Aminophylline,46 migraine,Valrubicin,46 -migraine,Dexamethasone,46 -migraine,Ticagrelor,46 -migraine,Melphalan,46 -migraine,Cyclosporine,46 -migraine,Diltiazem,46 -hypothyroidism,Diltiazem,44 -focal segmental glomerulosclerosis,Clopidogrel,44 -hypothyroidism,Cyclosporine,44 -hypothyroidism,Ticagrelor,44 -hypothyroidism,Clopidogrel,44 -hypothyroidism,Melphalan,44 -focal segmental glomerulosclerosis,Melphalan,44 -hypothyroidism,Bendroflumethiazide,44 +migraine,Oxcarbazepine,46 +migraine,Anagrelide,46 +migraine,Midazolam,46 +migraine,Primidone,46 +migraine,Propofol,46 +hypothyroidism,Primidone,44 +hypothyroidism,Benazepril,44 +hypothyroidism,Midazolam,44 +hypothyroidism,Ketotifen,44 +hypothyroidism,Anagrelide,44 +hypothyroidism,Oxcarbazepine,44 hypothyroidism,Valrubicin,44 -hypothyroidism,Teniposide,44 -hypothyroidism,Dexamethasone,44 -focal segmental glomerulosclerosis,Diltiazem,44 -focal segmental glomerulosclerosis,Bendroflumethiazide,44 -focal segmental glomerulosclerosis,Ticagrelor,44 -focal segmental glomerulosclerosis,Dexamethasone,44 -focal segmental glomerulosclerosis,Valrubicin,44 -focal segmental glomerulosclerosis,Teniposide,44 -focal segmental glomerulosclerosis,Dipivefrin,44 -focal segmental glomerulosclerosis,Clobetasol propionate,44 -hypothyroidism,Propylthiouracil,44 -bile duct cancer,Clopidogrel,42 -muscle cancer,Diltiazem,42 -muscle cancer,Cyclosporine,42 -muscle cancer,Teniposide,42 -muscle cancer,Ticagrelor,42 -muscle cancer,Dexamethasone,42 -muscle cancer,Valrubicin,42 -muscle cancer,Bendroflumethiazide,42 -muscle cancer,Dipivefrin,42 -muscle cancer,Clopidogrel,42 -bile duct cancer,Valrubicin,42 -muscle cancer,Melphalan,42 -bile duct cancer,Diltiazem,42 -bile duct cancer,Melphalan,42 -bile duct cancer,Dipivefrin,42 -bile duct cancer,Bendroflumethiazide,42 -bile duct cancer,Dexamethasone,42 -bile duct cancer,Ticagrelor,42 -bile duct cancer,Teniposide,42 -bile duct cancer,Cyclosporine,42 -adrenal gland cancer,Teniposide,38 -adrenal gland cancer,Clopidogrel,38 -adrenal gland cancer,Dipivefrin,38 -adrenal gland cancer,Bendroflumethiazide,38 +hypothyroidism,Aminophylline,44 +hypothyroidism,Levetiracetam,44 +hypothyroidism,Propofol,44 +cervical cancer,Propofol,42 +cervical cancer,Primidone,42 +cervical cancer,Levetiracetam,42 +cervical cancer,Aminophylline,42 +cervical cancer,Valrubicin,42 +cervical cancer,Oxcarbazepine,42 +cervical cancer,Anagrelide,42 +cervical cancer,Ketotifen,42 +cervical cancer,Midazolam,42 +cervical cancer,Benazepril,42 +allergic rhinitis,Anagrelide,41 +allergic rhinitis,Pimecrolimus,41 +allergic rhinitis,Aminophylline,41 +attention deficit hyperactivity disorder,Benazepril,41 +allergic rhinitis,Ketotifen,41 +allergic rhinitis,Benazepril,41 +allergic rhinitis,WF10,41 +allergic rhinitis,Nilutamide,41 +allergic rhinitis,Glimepiride,41 +attention deficit hyperactivity disorder,Midazolam,41 +attention deficit hyperactivity disorder,Ketotifen,41 +attention deficit hyperactivity disorder,Anagrelide,41 +attention deficit hyperactivity disorder,Oxcarbazepine,41 +attention deficit hyperactivity disorder,Valrubicin,41 +attention deficit hyperactivity disorder,Aminophylline,41 +attention deficit hyperactivity disorder,Levetiracetam,41 +allergic rhinitis,Dactinomycin,41 +allergic rhinitis,Clopidogrel,41 +attention deficit hyperactivity disorder,Primidone,41 +attention deficit hyperactivity disorder,Propofol,41 +adrenal gland cancer,Propofol,38 adrenal gland cancer,Valrubicin,38 -adrenal gland cancer,Dexamethasone,38 -adrenal gland cancer,Ticagrelor,38 -adrenal gland cancer,Melphalan,38 -adrenal gland cancer,Cyclosporine,38 -adrenal gland cancer,Diltiazem,38 -Graves' disease,Dexamethasone,34 -Graves' disease,Ticagrelor,34 -Graves' disease,Melphalan,34 -Graves' disease,Dipivefrin,34 -Graves' disease,Clopidogrel,34 -Graves' disease,Bendroflumethiazide,34 -Graves' disease,Diltiazem,34 -Graves' disease,Cyclosporine,34 +adrenal gland cancer,Primidone,38 +adrenal gland cancer,Levetiracetam,38 +adrenal gland cancer,Aminophylline,38 +adrenal gland cancer,Oxcarbazepine,38 +vitiligo,Levetiracetam,38 +adrenal gland cancer,Anagrelide,38 +adrenal gland cancer,Ketotifen,38 +adrenal gland cancer,Midazolam,38 +adrenal gland cancer,Benazepril,38 +vitiligo,Benazepril,38 +vitiligo,Midazolam,38 +vitiligo,Ketotifen,38 +vitiligo,Anagrelide,38 +vitiligo,Oxcarbazepine,38 +vitiligo,Valrubicin,38 +vitiligo,Aminophylline,38 +vitiligo,Primidone,38 +vitiligo,Propofol,38 +Graves' disease,Anagrelide,34 +Graves' disease,Propofol,34 +Graves' disease,Oxcarbazepine,34 +Graves' disease,Levetiracetam,34 +Graves' disease,Ketotifen,34 +Graves' disease,Midazolam,34 +Graves' disease,Benazepril,34 +Graves' disease,Primidone,34 Graves' disease,Valrubicin,34 -Graves' disease,Teniposide,34 -endogenous depression,Clopidogrel,33 -endogenous depression,Teniposide,33 -endogenous depression,Melphalan,33 -endogenous depression,Cyclosporine,33 -endogenous depression,Diltiazem,33 -endogenous depression,Dipivefrin,33 -endogenous depression,Bendroflumethiazide,33 +Graves' disease,Aminophylline,34 +endogenous depression,Ketotifen,33 +endogenous depression,Anagrelide,33 +endogenous depression,Oxcarbazepine,33 endogenous depression,Valrubicin,33 -endogenous depression,Dexamethasone,33 -endogenous depression,Ticagrelor,33 -meningioma,Dipivefrin,28 -meningioma,Melphalan,28 -meningioma,Diltiazem,28 -meningioma,Teniposide,28 -meningioma,Cyclosporine,28 -meningioma,Ticagrelor,28 -meningioma,Dexamethasone,28 +endogenous depression,Aminophylline,33 +endogenous depression,Levetiracetam,33 +endogenous depression,Midazolam,33 +endogenous depression,Benazepril,33 +endogenous depression,Propofol,33 +endogenous depression,Primidone,33 +meningioma,Propofol,28 +meningioma,Primidone,28 +meningioma,Levetiracetam,28 +meningioma,Aminophylline,28 meningioma,Valrubicin,28 -meningioma,Bendroflumethiazide,28 -meningioma,Clopidogrel,28 -narcolepsy,Clopidogrel,27 -narcolepsy,Dexamethasone,27 -narcolepsy,Ticagrelor,27 -narcolepsy,Teniposide,27 -narcolepsy,Cyclosporine,27 -narcolepsy,Diltiazem,27 -narcolepsy,Bendroflumethiazide,27 -narcolepsy,Dipivefrin,27 +meningioma,Oxcarbazepine,28 +meningioma,Ketotifen,28 +meningioma,Midazolam,28 +meningioma,Benazepril,28 +meningioma,Anagrelide,28 +membranous glomerulonephritis,Midazolam,27 +membranous glomerulonephritis,Oxcarbazepine,27 +membranous glomerulonephritis,Ketotifen,27 +membranous glomerulonephritis,Propofol,27 +membranous glomerulonephritis,Benazepril,27 +membranous glomerulonephritis,Valrubicin,27 +narcolepsy,Benazepril,27 +narcolepsy,Midazolam,27 +narcolepsy,Ketotifen,27 +narcolepsy,Anagrelide,27 +narcolepsy,Oxcarbazepine,27 narcolepsy,Valrubicin,27 -narcolepsy,Melphalan,27 -nephrolithiasis,Irinotecan,26 -nephrolithiasis,Melphalan,26 -nephrolithiasis,Diltiazem,26 -nephrolithiasis,Teniposide,26 -nephrolithiasis,Cyclosporine,26 -nephrolithiasis,Zonisamide,26 -nephrolithiasis,Dexamethasone,26 -nephrolithiasis,Erlotinib,26 -nephrolithiasis,Primidone,26 -nephrolithiasis,Bendroflumethiazide,26 -leprosy,Ticagrelor,23 -testicular cancer,Cyclosporine,23 -leprosy,Cyclosporine,23 -leprosy,Diltiazem,23 +narcolepsy,Aminophylline,27 +narcolepsy,Levetiracetam,27 +narcolepsy,Primidone,27 +narcolepsy,Propofol,27 +membranous glomerulonephritis,Aminophylline,27 +membranous glomerulonephritis,Levetiracetam,27 +membranous glomerulonephritis,Primidone,27 +membranous glomerulonephritis,Anagrelide,27 testicular cancer,Valrubicin,23 -testicular cancer,Dexamethasone,23 -testicular cancer,Ticagrelor,23 -leprosy,Clopidogrel,23 -testicular cancer,Teniposide,23 -leprosy,Melphalan,23 -testicular cancer,Diltiazem,23 +testicular cancer,Anagrelide,23 +testicular cancer,Benazepril,23 +testicular cancer,Aminophylline,23 +testicular cancer,Methylprednisolone,23 +testicular cancer,Losartan,23 +testicular cancer,Carbachol,23 testicular cancer,Clopidogrel,23 -testicular cancer,Melphalan,23 -leprosy,Teniposide,23 -intracranial aneurysm,Melphalan,23 -leprosy,Dexamethasone,23 -leprosy,Valrubicin,23 -leprosy,Bendroflumethiazide,23 -intracranial aneurysm,Diltiazem,23 -leprosy,Dipivefrin,23 -intracranial aneurysm,Dipivefrin,23 -intracranial aneurysm,Clopidogrel,23 -testicular cancer,Dipivefrin,23 -intracranial aneurysm,Bendroflumethiazide,23 -intracranial aneurysm,Valrubicin,23 -intracranial aneurysm,Dexamethasone,23 -intracranial aneurysm,Ticagrelor,23 -intracranial aneurysm,Teniposide,23 -intracranial aneurysm,Cyclosporine,23 -testicular cancer,Bendroflumethiazide,23 -thymus cancer,Dipivefrin,19 -thymus cancer,Bendroflumethiazide,19 +testicular cancer,Acebutolol,23 +testicular cancer,Nilutamide,23 +Behcet's disease,Benazepril,21 +Behcet's disease,Midazolam,21 +Behcet's disease,Ketotifen,21 +Behcet's disease,Anagrelide,21 +Behcet's disease,Oxcarbazepine,21 +Behcet's disease,Propofol,21 +Behcet's disease,Valrubicin,21 +Behcet's disease,Aminophylline,21 +Behcet's disease,Levetiracetam,21 +Behcet's disease,Primidone,21 +thymus cancer,Aminophylline,19 thymus cancer,Valrubicin,19 -thymus cancer,Dexamethasone,19 -thymus cancer,Ticagrelor,19 -thymus cancer,Teniposide,19 -thymus cancer,Cyclosporine,19 -thymus cancer,Diltiazem,19 -thymus cancer,Clopidogrel,19 -thymus cancer,Melphalan,19 -gout,Ticagrelor,18 -gout,Melphalan,18 -gout,Clopidogrel,18 -gout,Diltiazem,18 -gout,Teniposide,18 -gout,Cyclosporine,18 -gout,Dexamethasone,18 -gout,Bendroflumethiazide,18 +thymus cancer,Propofol,19 +thymus cancer,Levetiracetam,19 +thymus cancer,Anagrelide,19 +thymus cancer,Ketotifen,19 +thymus cancer,Midazolam,19 +thymus cancer,Benazepril,19 +thymus cancer,Oxcarbazepine,19 +thymus cancer,Primidone,19 gout,Primidone,18 -gout,Clobetasol propionate,18 -gestational diabetes,Bendroflumethiazide,17 -gestational diabetes,Teniposide,17 -gestational diabetes,Dipivefrin,17 -gestational diabetes,Dexamethasone,17 -rectum cancer,Melphalan,17 -gestational diabetes,Cyclosporine,17 -gestational diabetes,Diltiazem,17 -gestational diabetes,Clopidogrel,17 -gestational diabetes,Melphalan,17 -rectum cancer,Dipivefrin,17 -rectum cancer,Clopidogrel,17 -gestational diabetes,Ticagrelor,17 -rectum cancer,Diltiazem,17 -rectum cancer,Teniposide,17 -rectum cancer,Cyclosporine,17 -rectum cancer,Ticagrelor,17 -rectum cancer,Dexamethasone,17 -rectum cancer,Valrubicin,17 -rectum cancer,Bendroflumethiazide,17 +gout,Levetiracetam,18 +gout,Aminophylline,18 +gout,Oxcarbazepine,18 +gout,Anagrelide,18 +gout,Ketotifen,18 +gout,Benazepril,18 +gout,Midazolam,18 +gout,Pimecrolimus,18 +gout,Propofol,18 +rectum cancer,Anagrelide,17 +gestational diabetes,Propofol,17 +gestational diabetes,Primidone,17 +gestational diabetes,Levetiracetam,17 +gestational diabetes,Aminophylline,17 gestational diabetes,Valrubicin,17 -Paget's disease of bone,Triamterene,16 -pharynx cancer,Dexamethasone,16 -panic disorder,Diltiazem,16 -panic disorder,Clopidogrel,16 -panic disorder,Melphalan,16 -pharynx cancer,Dipivefrin,16 -pharynx cancer,Bendroflumethiazide,16 -pharynx cancer,Valrubicin,16 -pharynx cancer,Diltiazem,16 -pharynx cancer,Ticagrelor,16 -pharynx cancer,Teniposide,16 -pharynx cancer,Cyclosporine,16 +gestational diabetes,Oxcarbazepine,17 +gestational diabetes,Anagrelide,17 +gestational diabetes,Midazolam,17 +gestational diabetes,Benazepril,17 +rectum cancer,Oxcarbazepine,17 +rectum cancer,Valrubicin,17 +rectum cancer,Midazolam,17 +rectum cancer,Aminophylline,17 +rectum cancer,Levetiracetam,17 +rectum cancer,Primidone,17 +rectum cancer,Propofol,17 +rectum cancer,Methylprednisolone,17 +rectum cancer,Benazepril,17 +gestational diabetes,Ketotifen,17 +pharynx cancer,Primidone,16 +Paget's disease of bone,Aminophylline,16 Paget's disease of bone,Benazepril,16 -pharynx cancer,Clopidogrel,16 -pharynx cancer,Melphalan,16 -panic disorder,Teniposide,16 -panic disorder,Ticagrelor,16 -panic disorder,Dexamethasone,16 -Gilles de la Tourette syndrome,Diltiazem,16 -Paget's disease of bone,Clobetasol propionate,16 -Paget's disease of bone,Dipivefrin,16 -Paget's disease of bone,Bendroflumethiazide,16 -Paget's disease of bone,Dexamethasone,16 -Paget's disease of bone,Cyclosporine,16 -Paget's disease of bone,Teniposide,16 -panic disorder,Triamterene,16 -Gilles de la Tourette syndrome,Melphalan,16 -Gilles de la Tourette syndrome,Clopidogrel,16 -Gilles de la Tourette syndrome,Teniposide,16 -panic disorder,Bendroflumethiazide,16 -Gilles de la Tourette syndrome,Bupropion,16 -Gilles de la Tourette syndrome,Ticagrelor,16 -Gilles de la Tourette syndrome,Medroxyprogesterone Acetate,16 -Gilles de la Tourette syndrome,Zonisamide,16 -Gilles de la Tourette syndrome,Dexamethasone,16 -Gilles de la Tourette syndrome,Irinotecan,16 -Paget's disease of bone,Melphalan,16 -panic disorder,Benazepril,16 -panic disorder,Primidone,16 -Paget's disease of bone,Diltiazem,16 -Kawasaki disease,Melphalan,14 -degenerative disc disease,Ticagrelor,14 +Paget's disease of bone,Ketotifen,16 +Paget's disease of bone,Anagrelide,16 +Gilles de la Tourette syndrome,Torasemide,16 +Paget's disease of bone,Methylprednisolone,16 +Gilles de la Tourette syndrome,Guanadrel,16 +Paget's disease of bone,Acebutolol,16 +pharynx cancer,Aminophylline,16 +Paget's disease of bone,Glimepiride,16 +pharynx cancer,Oxcarbazepine,16 +pharynx cancer,Anagrelide,16 +pharynx cancer,Ketotifen,16 +pharynx cancer,Midazolam,16 +pharynx cancer,Benazepril,16 +Gilles de la Tourette syndrome,Progesterone,16 +Gilles de la Tourette syndrome,Oxcarbazepine,16 +Paget's disease of bone,Nilutamide,16 +Gilles de la Tourette syndrome,Vinblastine,16 +Gilles de la Tourette syndrome,Anagrelide,16 +Gilles de la Tourette syndrome,Cimetidine,16 +Gilles de la Tourette syndrome,Midazolam,16 +Gilles de la Tourette syndrome,Atorvastatin,16 +pharynx cancer,Levetiracetam,16 +Gilles de la Tourette syndrome,Benazepril,16 +Paget's disease of bone,Dactinomycin,16 +Paget's disease of bone,WF10,16 +pharynx cancer,Valrubicin,16 +pharynx cancer,Propofol,16 +Kawasaki disease,Propofol,14 +degenerative disc disease,Midazolam,14 +Kawasaki disease,Primidone,14 +Kawasaki disease,Benazepril,14 +Kawasaki disease,Midazolam,14 +Kawasaki disease,Ketotifen,14 +Kawasaki disease,Anagrelide,14 +Kawasaki disease,Oxcarbazepine,14 +Kawasaki disease,Aminophylline,14 +degenerative disc disease,Atorvastatin,14 Kawasaki disease,Valrubicin,14 -degenerative disc disease,Zonisamide,14 -degenerative disc disease,Dexamethasone,14 -degenerative disc disease,Irinotecan,14 -degenerative disc disease,Donepezil,14 -degenerative disc disease,Erlotinib,14 +degenerative disc disease,Vinblastine,14 +degenerative disc disease,Oxcarbazepine,14 +degenerative disc disease,Levetiracetam,14 degenerative disc disease,Primidone,14 -degenerative disc disease,Cyclosporine,14 -degenerative disc disease,Clopidogrel,14 -degenerative disc disease,Melphalan,14 -Kawasaki disease,Clopidogrel,14 -Kawasaki disease,Dipivefrin,14 -Kawasaki disease,Bendroflumethiazide,14 -Kawasaki disease,Dexamethasone,14 -Kawasaki disease,Ticagrelor,14 -Kawasaki disease,Teniposide,14 -Kawasaki disease,Cyclosporine,14 -Kawasaki disease,Diltiazem,14 -thoracic aortic aneurysm,Clopidogrel,13 -dental caries,Lomustine,13 -dental caries,Triamterene,13 -dental caries,Melphalan,13 -dental caries,Diltiazem,13 -dental caries,Benazepril,13 -dental caries,Teniposide,13 -dental caries,Cyclosporine,13 -dental caries,Dexamethasone,13 -thoracic aortic aneurysm,Melphalan,13 -thoracic aortic aneurysm,Bendroflumethiazide,13 -thoracic aortic aneurysm,Diltiazem,13 -thoracic aortic aneurysm,Valrubicin,13 -thoracic aortic aneurysm,Teniposide,13 -thoracic aortic aneurysm,Dipivefrin,13 -dental caries,Clobetasol propionate,13 -dental caries,Bendroflumethiazide,13 -thoracic aortic aneurysm,Dexamethasone,13 -thoracic aortic aneurysm,Ticagrelor,13 -thoracic aortic aneurysm,Cyclosporine,13 -restless legs syndrome,Clopidogrel,12 -restless legs syndrome,Diltiazem,12 -restless legs syndrome,Teniposide,12 -restless legs syndrome,Cyclosporine,12 -restless legs syndrome,Ticagrelor,12 -restless legs syndrome,Dexamethasone,12 -restless legs syndrome,Bendroflumethiazide,12 -restless legs syndrome,Melphalan,12 +degenerative disc disease,Propofol,14 +degenerative disc disease,Vigabatrin,14 +degenerative disc disease,Methylprednisolone,14 +Kawasaki disease,Levetiracetam,14 +degenerative disc disease,Lovastatin,14 +restless legs syndrome,Aminophylline,12 +restless legs syndrome,Ketotifen,12 +restless legs syndrome,Anagrelide,12 +restless legs syndrome,Oxcarbazepine,12 +restless legs syndrome,Propofol,12 +restless legs syndrome,Levetiracetam,12 restless legs syndrome,Primidone,12 -restless legs syndrome,Indomethacin,12 -lymphatic system cancer,Melphalan,9 -lymphatic system cancer,Bexarotene,9 -malignant mesothelioma,Clopidogrel,9 -malignant mesothelioma,Diltiazem,9 -malignant mesothelioma,Teniposide,9 -malignant mesothelioma,Bupropion,9 -malignant mesothelioma,Ticagrelor,9 -malignant mesothelioma,Cyclosporine,9 -malignant mesothelioma,Medroxyprogesterone Acetate,9 -malignant mesothelioma,Zonisamide,9 -malignant mesothelioma,Dexamethasone,9 -malignant mesothelioma,Melphalan,9 -lymphatic system cancer,Cyclosporine,9 -lymphatic system cancer,Bupropion,9 -lymphatic system cancer,Zonisamide,9 -lymphatic system cancer,Dexamethasone,9 -lymphatic system cancer,Irinotecan,9 -lymphatic system cancer,Erlotinib,9 +restless legs syndrome,Benazepril,12 +restless legs syndrome,Midazolam,12 +restless legs syndrome,Methylprednisolone,12 +conduct disorder,Benazepril,12 +conduct disorder,Guanadrel,12 +conduct disorder,Valrubicin,12 +conduct disorder,Vinblastine,12 +conduct disorder,Anagrelide,12 +conduct disorder,Cimetidine,12 +conduct disorder,Midazolam,12 +conduct disorder,Atorvastatin,12 +conduct disorder,Torasemide,12 +conduct disorder,Oxcarbazepine,12 +vascular cancer,Cimetidine,9 +vascular cancer,Midazolam,9 +vascular cancer,Guanadrel,9 +lymphatic system cancer,Methylprednisolone,9 +lymphatic system cancer,Vigabatrin,9 +lymphatic system cancer,Propofol,9 lymphatic system cancer,Primidone,9 -lymphatic system cancer,Fosphenytoin,9 -Creutzfeldt-Jakob disease,Dexamethasone,7 -Creutzfeldt-Jakob disease,Bendroflumethiazide,7 -Creutzfeldt-Jakob disease,Donepezil,7 -Creutzfeldt-Jakob disease,Irinotecan,7 -Creutzfeldt-Jakob disease,Cyclosporine,7 -Creutzfeldt-Jakob disease,Zonisamide,7 -Creutzfeldt-Jakob disease,Teniposide,7 -spinal cancer,Topotecan,7 -Creutzfeldt-Jakob disease,Diltiazem,7 -spinal cancer,Prednisolone,7 -spinal cancer,Vigabatrin,7 -Creutzfeldt-Jakob disease,Erlotinib,7 -spinal cancer,Fosphenytoin,7 -spinal cancer,Primidone,7 -spinal cancer,Erlotinib,7 -spinal cancer,Irinotecan,7 -spinal cancer,Dexamethasone,7 -Creutzfeldt-Jakob disease,Melphalan,7 -spinal cancer,Melphalan,7 -spinal cancer,Zonisamide,7 -vulva cancer,Irinotecan,6 -vulva cancer,Erlotinib,6 -vulva cancer,Idarubicin,6 -vulva cancer,Fulvestrant,6 -vulva cancer,Valrubicin,6 -vulva cancer,Dactinomycin,6 -Fuchs' endothelial dystrophy,Clobetasol propionate,6 -vulva cancer,Fluoxymesterone,6 -Fuchs' endothelial dystrophy,Cyclosporine,6 -Fuchs' endothelial dystrophy,Fosphenytoin,6 -vulva cancer,Teniposide,6 -Fuchs' endothelial dystrophy,Irinotecan,6 -Fuchs' endothelial dystrophy,Dexamethasone,6 -Fuchs' endothelial dystrophy,Zonisamide,6 +lymphatic system cancer,Levetiracetam,9 +lymphatic system cancer,Oxcarbazepine,9 +lymphatic system cancer,Anagrelide,9 +malignant mesothelioma,Benazepril,9 +malignant mesothelioma,Atorvastatin,9 +malignant mesothelioma,Midazolam,9 +malignant mesothelioma,Cimetidine,9 +malignant mesothelioma,Vinblastine,9 +malignant mesothelioma,Anagrelide,9 +vascular cancer,Torasemide,9 +vascular cancer,Benazepril,9 +vascular cancer,Acitretin,9 +malignant mesothelioma,Oxcarbazepine,9 +vascular cancer,Atorvastatin,9 +lymphatic system cancer,Vinblastine,9 +lymphatic system cancer,Midazolam,9 +lymphatic system cancer,Cimetidine,9 +malignant mesothelioma,Valrubicin,9 +malignant mesothelioma,Guanadrel,9 +vascular cancer,Oxcarbazepine,9 +vascular cancer,Anagrelide,9 +vascular cancer,Vinblastine,9 +malignant mesothelioma,Torasemide,9 +Creutzfeldt-Jakob disease,Guanadrel,7 +Creutzfeldt-Jakob disease,Benazepril,7 +Creutzfeldt-Jakob disease,Atorvastatin,7 +Creutzfeldt-Jakob disease,Midazolam,7 +Creutzfeldt-Jakob disease,Ketotifen,7 +Creutzfeldt-Jakob disease,Vinblastine,7 +Creutzfeldt-Jakob disease,Anagrelide,7 +Creutzfeldt-Jakob disease,Oxcarbazepine,7 +Creutzfeldt-Jakob disease,Aminophylline,7 +Creutzfeldt-Jakob disease,Torasemide,7 +Fuchs' endothelial dystrophy,Vinblastine,6 +Fuchs' endothelial dystrophy,Acitretin,6 +Fuchs' endothelial dystrophy,Midazolam,6 +Fuchs' endothelial dystrophy,Anagrelide,6 Fuchs' endothelial dystrophy,Primidone,6 -Fuchs' endothelial dystrophy,Teniposide,6 -Fuchs' endothelial dystrophy,Vorinostat,6 -Fuchs' endothelial dystrophy,Melphalan,6 -vulva cancer,Melphalan,6 -vulva cancer,Chenodeoxycholic acid,6 -larynx cancer,Bendroflumethiazide,5 -larynx cancer,Melphalan,5 -larynx cancer,Diltiazem,5 -larynx cancer,Teniposide,5 -larynx cancer,Cyclosporine,5 -larynx cancer,Medroxyprogesterone Acetate,5 -larynx cancer,Dexamethasone,5 -larynx cancer,Irinotecan,5 -larynx cancer,Donepezil,5 -larynx cancer,Dipivefrin,5 -otosclerosis,Melphalan,4 -nasal cavity cancer,Stavudine,4 -otosclerosis,Dexamethasone,4 -duodenum cancer,Benazepril,4 -nasal cavity cancer,Balsalazide,4 -nasal cavity cancer,Mercaptopurine,4 -nasal cavity cancer,Nicotine,4 -otosclerosis,Clopidogrel,4 -nasal cavity cancer,Indinavir,4 -nasal cavity cancer,Efavirenz,4 -nasal cavity cancer,Dexamethasone,4 -nasal cavity cancer,Zidovudine,4 +Fuchs' endothelial dystrophy,Oxcarbazepine,6 +Fuchs' endothelial dystrophy,Budesonide,6 +Fuchs' endothelial dystrophy,Levetiracetam,6 +Fuchs' endothelial dystrophy,Propofol,6 +Fuchs' endothelial dystrophy,Dexamethasone,6 +appendix cancer,Altretamine,4 +nasal cavity cancer,Budesonide,4 +nasal cavity cancer,Nelfinavir,4 nasal cavity cancer,Azathioprine,4 -otosclerosis,Benazepril,4 -otosclerosis,Primidone,4 -otosclerosis,Bendroflumethiazide,4 -nasal cavity cancer,Prednisone,4 -otosclerosis,Ticagrelor,4 -duodenum cancer,Dexamethasone,4 -duodenum cancer,Erlotinib,4 -duodenum cancer,Primidone,4 -duodenum cancer,Bendroflumethiazide,4 -otosclerosis,Cyclosporine,4 -duodenum cancer,Donepezil,4 -duodenum cancer,Irinotecan,4 -duodenum cancer,Zonisamide,4 -duodenum cancer,Diltiazem,4 -otosclerosis,Diltiazem,4 -otosclerosis,Teniposide,4 -duodenum cancer,Fosphenytoin,4 -fallopian tube cancer,Irinotecan,3 -fallopian tube cancer,Nilutamide,3 -fallopian tube cancer,Fluoxymesterone,3 -fallopian tube cancer,Melphalan,3 -fallopian tube cancer,Erlotinib,3 -fallopian tube cancer,Fulvestrant,3 -fallopian tube cancer,Idarubicin,3 -fallopian tube cancer,Prednisone,3 -fallopian tube cancer,Etoposide,3 -vaginal cancer,Bexarotene,3 -vaginal cancer,Dimenhydrinate,3 -fallopian tube cancer,Dactinomycin,3 -vaginal cancer,Erlotinib,3 -vaginal cancer,Clobetasol propionate,3 -retroperitoneal cancer,Melphalan,3 -retroperitoneal cancer,Vorinostat,3 +nasal cavity cancer,Olsalazine,4 +nasal cavity cancer,Balsalazide,4 +nasal cavity cancer,Stavudine,4 +nasal cavity cancer,Triamcinolone,4 +nasal cavity cancer,Mercaptopurine,4 +appendix cancer,Pazopanib,4 +appendix cancer,Vinblastine,4 +appendix cancer,Dexamethasone,4 +appendix cancer,Valrubicin,4 +appendix cancer,Budesonide,4 +appendix cancer,Methylprednisolone,4 +appendix cancer,Floxuridine,4 +appendix cancer,Dactinomycin,4 +appendix cancer,Epirubicin,4 +nasal cavity cancer,Sulfasalazine,4 +nasal cavity cancer,Dexamethasone,4 +vaginal cancer,WF10,3 +fallopian tube cancer,Ethinyl Estradiol,3 +vaginal cancer,Nilutamide,3 +fallopian tube cancer,Degarelix,3 +retroperitoneal cancer,Azathioprine,3 retroperitoneal cancer,Teniposide,3 -retroperitoneal cancer,Cladribine,3 -retroperitoneal cancer,Dexamethasone,3 +retroperitoneal cancer,Olsalazine,3 +retroperitoneal cancer,Balsalazide,3 +retroperitoneal cancer,Carboplatin,3 +retroperitoneal cancer,Anagrelide,3 +retroperitoneal cancer,Vinblastine,3 +retroperitoneal cancer,Daunorubicin,3 +fallopian tube cancer,Cisplatin,3 +fallopian tube cancer,Vinblastine,3 +fallopian tube cancer,Carboplatin,3 +fallopian tube cancer,Ixabepilone,3 retroperitoneal cancer,Irinotecan,3 -retroperitoneal cancer,Pentostatin,3 -retroperitoneal cancer,Idarubicin,3 -retroperitoneal cancer,Prednisone,3 -vaginal cancer,Melphalan,3 -vaginal cancer,Teniposide,3 -vaginal cancer,Cyclosporine,3 -vaginal cancer,Dexamethasone,3 -vaginal cancer,Irinotecan,3 +fallopian tube cancer,Thiotepa,3 +fallopian tube cancer,Estradiol valerate/Dienogest,3 +fallopian tube cancer,Irinotecan,3 +vaginal cancer,Methylprednisolone,3 +retroperitoneal cancer,Fludarabine,3 +vaginal cancer,Pimecrolimus,3 +vaginal cancer,Aminophylline,3 vaginal cancer,Valrubicin,3 -retroperitoneal cancer,Bexarotene,3 -penile cancer,Imiquimod,2 +vaginal cancer,Vinblastine,3 +vaginal cancer,Anagrelide,3 +vaginal cancer,Ketotifen,3 +fallopian tube cancer,Pazopanib,3 +vaginal cancer,Acitretin,3 penile cancer,Irinotecan,2 -penile cancer,Vismodegib,2 -penile cancer,Fluoxymesterone,2 -penile cancer,Dactinomycin,2 -penile cancer,Fulvestrant,2 +penile cancer,Carboplatin,2 +penile cancer,Ixabepilone,2 +penile cancer,Vinblastine,2 +penile cancer,Tamoxifen,2 penile cancer,Idarubicin,2 -penile cancer,Thiotepa,2 -penile cancer,Mitoxantrone,2 -penile cancer,Melphalan,2 +penile cancer,Raloxifene,2 +penile cancer,Imiquimod,2 +penile cancer,Vemurafenib,2 +penile cancer,Vismodegib,2 tracheal cancer,Clomifene,1 -peritoneum cancer,Doxorubicin,1 -peritoneum cancer,Vigabatrin,1 -peritoneum cancer,Fosphenytoin,1 -peritoneum cancer,Oxcarbazepine,1 -peritoneum cancer,Valproic Acid,1 -peritoneum cancer,Topotecan,1 -peritoneum cancer,Primidone,1 -peritoneum cancer,Zonisamide,1 -peritoneum cancer,Vinorelbine,1 +ureter cancer,Bleomycin,1 +middle ear cancer,Zidovudine,1 +middle ear cancer,Teniposide,1 +middle ear cancer,Gemcitabine,1 +middle ear cancer,Docetaxel,1 +middle ear cancer,Delavirdine,1 +middle ear cancer,Nelfinavir,1 +middle ear cancer,Cisplatin,1 +middle ear cancer,Crizotinib,1 +middle ear cancer,Vinblastine,1 +middle ear cancer,Irinotecan,1 +ureter cancer,Irinotecan,1 ureter cancer,Vemurafenib,1 +ureter cancer,Memantine,1 ureter cancer,Clomifene,1 -ureter cancer,Temozolomide,1 ureter cancer,Dactinomycin,1 ureter cancer,Donepezil,1 -ureter cancer,Galantamine,1 -ureter cancer,Rivastigmine,1 -ureter cancer,Irinotecan,1 -ureter cancer,Capecitabine,1 ureter cancer,Carmustine,1 -peritoneum cancer,Melphalan,1 +ureter cancer,Methotrexate,1 +ureter cancer,Fluorouracil,1 diff --git a/neo4j_csv/analysis_super_drugs.csv b/neo4j_csv/analysis_super_drugs.csv index 7f77076..80ac2db 100644 --- a/neo4j_csv/analysis_super_drugs.csv +++ b/neo4j_csv/analysis_super_drugs.csv @@ -2,22 +2,22 @@ name,num_diseases_treated,num_side_effects,super_score Dacarbazine,7,0,7.0 Sulfasalazine,4,0,4.0 Cholecalciferol,3,0,3.0 -Cytarabine,2,0,2.0 Atorvastatin,2,0,2.0 +Cytarabine,2,0,2.0 Balsalazide,2,0,2.0 Carboplatin,9,7,1.125 +Eribulin,1,0,1.0 +Guanethidine,1,0,1.0 Doxycycline,1,0,1.0 Isoetarine,1,0,1.0 -Moexipril,1,0,1.0 Olsalazine,1,0,1.0 -Rifampicin,1,0,1.0 -Vitamin C,1,0,1.0 -Eribulin,1,0,1.0 Artemether,1,0,1.0 -Guanethidine,1,0,1.0 +Moexipril,1,0,1.0 Lopinavir,1,0,1.0 -Guanadrel,1,0,1.0 +Rifampicin,1,0,1.0 Minoxidil,1,0,1.0 +Guanadrel,1,0,1.0 +Vitamin C,1,0,1.0 Physostigmine,1,6,0.14285714285714285 Dactinomycin,10,75,0.13157894736842105 Vinblastine,7,59,0.11666666666666667 @@ -39,17 +39,17 @@ Methoxsalen,3,53,0.05555555555555555 Mercaptopurine,3,57,0.05172413793103448 Penbutolol,2,39,0.05 Vincristine,7,142,0.04895104895104895 -Chlorambucil,4,83,0.047619047619047616 Tiludronate,1,20,0.047619047619047616 +Chlorambucil,4,83,0.047619047619047616 Cisplatin,8,169,0.047058823529411764 Methylprednisolone,10,216,0.04608294930875576 +Calcipotriol,1,21,0.045454545454545456 Beclomethasone,2,43,0.045454545454545456 Methamphetamine,1,21,0.045454545454545456 -Calcipotriol,1,21,0.045454545454545456 Fluocinonide,2,44,0.044444444444444446 Lomustine,2,44,0.044444444444444446 -Dexamethasone,11,249,0.044 Betamethasone,11,249,0.044 +Dexamethasone,11,249,0.044 Teniposide,3,70,0.04225352112676056 Miglitol,1,23,0.041666666666666664 Benzphetamine,1,23,0.041666666666666664 @@ -58,16 +58,16 @@ Loratadine,3,73,0.04054054054054054 Mechlorethamine,2,49,0.04 Auranofin,2,50,0.0392156862745098 Altretamine,1,25,0.038461538461538464 -Topotecan,4,111,0.03571428571428571 Dyphylline,1,27,0.03571428571428571 +Topotecan,4,111,0.03571428571428571 Mecamylamine,1,27,0.03571428571428571 Spironolactone,2,56,0.03508771929824561 +Proguanil,1,28,0.034482758620689655 +Triamterene,1,28,0.034482758620689655 +Probenecid,1,28,0.034482758620689655 Hydrocortisone,8,231,0.034482758620689655 Diphenhydramine,2,57,0.034482758620689655 Dimenhydrinate,2,57,0.034482758620689655 -Triamterene,1,28,0.034482758620689655 -Probenecid,1,28,0.034482758620689655 -Proguanil,1,28,0.034482758620689655 Melphalan,4,117,0.03389830508474576 Irinotecan,6,177,0.033707865168539325 Mitoxantrone,6,177,0.033707865168539325 @@ -88,43 +88,43 @@ Bendroflumethiazide,1,34,0.02857142857142857 Carmustine,5,177,0.028089887640449437 Mometasone,3,107,0.027777777777777776 Epirubicin,14,511,0.02734375 -Valsartan,3,110,0.02702702702702703 Methimazole,1,36,0.02702702702702703 +Valsartan,3,110,0.02702702702702703 Acetazolamide,2,74,0.02666666666666667 Tolazamide,1,38,0.02564102564102564 -Chlorpropamide,1,38,0.02564102564102564 Metipranolol,1,38,0.02564102564102564 +Chlorpropamide,1,38,0.02564102564102564 Linagliptin,1,39,0.025 -Disulfiram,1,39,0.025 Propantheline,1,39,0.025 +Disulfiram,1,39,0.025 Rosuvastatin,2,80,0.024691358024691357 Hydroflumethiazide,1,40,0.024390243902439025 Vinorelbine,4,164,0.024242424242424242 Amobarbital,1,41,0.023809523809523808 Acarbose,1,42,0.023255813953488372 Acetylsalicylic acid,2,86,0.022988505747126436 -Reserpine,1,43,0.022727272727272728 Phenylpropanolamine,1,43,0.022727272727272728 Ethacrynic acid,1,43,0.022727272727272728 +Reserpine,1,43,0.022727272727272728 Montelukast,3,132,0.022556390977443608 Colchicine,2,88,0.02247191011235955 Calcium Acetate,1,44,0.022222222222222223 Ruxolitinib,1,44,0.022222222222222223 Vemurafenib,2,90,0.02197802197802198 -Primidone,1,45,0.021739130434782608 Tazarotene,1,45,0.021739130434782608 +Primidone,1,45,0.021739130434782608 Thiotepa,4,184,0.021621621621621623 Metformin,3,139,0.02142857142857143 -Carteolol,1,46,0.02127659574468085 Nateglinide,1,46,0.02127659574468085 +Carteolol,1,46,0.02127659574468085 Alendronate,2,94,0.021052631578947368 -Aminophylline,2,95,0.020833333333333332 Fenoldopam,1,47,0.020833333333333332 -Ketotifen,1,48,0.02040816326530612 +Aminophylline,2,95,0.020833333333333332 Diclofenamide,1,48,0.02040816326530612 +Ketotifen,1,48,0.02040816326530612 Phentermine,1,48,0.02040816326530612 -Raloxifene,2,98,0.020202020202020204 Idarubicin,2,98,0.020202020202020204 +Raloxifene,2,98,0.020202020202020204 Captopril,3,148,0.020134228187919462 Pitavastatin,1,49,0.02 Erlotinib,3,152,0.0196078431372549 @@ -132,39 +132,39 @@ Nebivolol,1,50,0.0196078431372549 Glyburide,2,102,0.019417475728155338 Ramipril,4,206,0.01932367149758454 Carbachol,1,51,0.019230769230769232 -Desonide,1,52,0.018867924528301886 Valrubicin,1,52,0.018867924528301886 +Desonide,1,52,0.018867924528301886 Zileuton,1,52,0.018867924528301886 Calcitriol,2,106,0.018691588785046728 Levobunolol,1,53,0.018518518518518517 Timolol,4,218,0.0182648401826484 -Propylthiouracil,1,54,0.01818181818181818 Vismodegib,1,54,0.01818181818181818 +Propylthiouracil,1,54,0.01818181818181818 Indacaterol,1,54,0.01818181818181818 Tiotropium,2,110,0.018018018018018018 Orciprenaline,1,55,0.017857142857142856 Pentoxifylline,2,111,0.017857142857142856 Propranolol,2,112,0.017699115044247787 Furosemide,3,171,0.01744186046511628 -Torasemide,1,58,0.01694915254237288 Nedocromil,1,58,0.01694915254237288 -Pirbuterol,1,59,0.016666666666666666 +Torasemide,1,58,0.01694915254237288 Methazolamide,1,59,0.016666666666666666 +Pirbuterol,1,59,0.016666666666666666 Temozolomide,4,241,0.01652892561983471 Lovastatin,2,121,0.01639344262295082 Losartan,3,187,0.015957446808510637 -Trimethadione,1,62,0.015873015873015872 Chlorothiazide,1,62,0.015873015873015872 +Trimethadione,1,62,0.015873015873015872 Ezetimibe,2,127,0.015625 Entecavir,1,63,0.015625 Latanoprost,1,64,0.015384615384615385 Chlorthalidone,1,65,0.015151515151515152 -Fluticasone furoate,1,65,0.015151515151515152 Lisinopril,4,263,0.015151515151515152 +Fluticasone furoate,1,65,0.015151515151515152 Sorafenib,3,198,0.01507537688442211 Bumetanide,1,66,0.014925373134328358 -Estramustine,1,66,0.014925373134328358 Repaglinide,1,66,0.014925373134328358 +Estramustine,1,66,0.014925373134328358 Prazosin,1,66,0.014925373134328358 Flunisolide,2,133,0.014925373134328358 Eplerenone,2,134,0.014814814814814815 @@ -172,25 +172,25 @@ Vorinostat,1,67,0.014705882352941176 Adefovir Dipivoxil,1,67,0.014705882352941176 Cyproheptadine,1,68,0.014492753623188406 Procarbazine,2,137,0.014492753623188406 -Clobetasol propionate,1,68,0.014492753623188406 Diethylpropion,1,68,0.014492753623188406 +Clobetasol propionate,1,68,0.014492753623188406 Verapamil,2,138,0.014388489208633094 Roflumilast,1,69,0.014285714285714285 -Dextrothyroxine,1,71,0.013888888888888888 -Abiraterone,1,71,0.013888888888888888 Levothyroxine,1,71,0.013888888888888888 -Simvastatin,2,143,0.013888888888888888 +Abiraterone,1,71,0.013888888888888888 Fluocinolone Acetonide,2,143,0.013888888888888888 -Fludarabine,2,145,0.0136986301369863 +Simvastatin,2,143,0.013888888888888888 +Dextrothyroxine,1,71,0.013888888888888888 Floxuridine,1,72,0.0136986301369863 +Fludarabine,2,145,0.0136986301369863 Lapatinib,1,73,0.013513513513513514 Amprenavir,1,73,0.013513513513513514 Desloratadine,1,73,0.013513513513513514 Estrone,1,74,0.013333333333333334 -Rosiglitazone,1,76,0.012987012987012988 -Bepridil,1,76,0.012987012987012988 -Zafirlukast,1,76,0.012987012987012988 Ethinyl Estradiol,2,153,0.012987012987012988 +Rosiglitazone,1,76,0.012987012987012988 +Zafirlukast,1,76,0.012987012987012988 +Bepridil,1,76,0.012987012987012988 Cimetidine,1,77,0.01282051282051282 Sulfadiazine,1,78,0.012658227848101266 Leflunomide,3,240,0.012448132780082987 @@ -201,21 +201,21 @@ Candesartan,1,83,0.011904761904761904 Phenobarbital,1,84,0.011764705882352941 Orlistat,2,170,0.011695906432748537 Cyclosporine,4,344,0.011594202898550725 -Theophylline,1,86,0.011494252873563218 Methyldopa,1,86,0.011494252873563218 +Theophylline,1,86,0.011494252873563218 Niacin,2,177,0.011235955056179775 Rufinamide,1,88,0.011235955056179775 Nilutamide,1,89,0.011111111111111112 -Fingolimod,1,90,0.01098901098901099 -Fulvestrant,1,90,0.01098901098901099 Amiloride,1,90,0.01098901098901099 -Flutamide,1,90,0.01098901098901099 +Fulvestrant,1,90,0.01098901098901099 +Fingolimod,1,90,0.01098901098901099 Hydralazine,1,90,0.01098901098901099 +Flutamide,1,90,0.01098901098901099 Pravastatin,2,184,0.010810810810810811 -Didanosine,1,92,0.010752688172043012 Pamidronate,2,185,0.010752688172043012 -Clonidine,2,186,0.0106951871657754 +Didanosine,1,92,0.010752688172043012 Cladribine,2,186,0.0106951871657754 +Clonidine,2,186,0.0106951871657754 Toremifene,1,93,0.010638297872340425 Pindolol,1,93,0.010638297872340425 Formoterol,2,188,0.010582010582010581 @@ -227,18 +227,18 @@ Crizotinib,1,99,0.01 Enalapril,2,200,0.009950248756218905 Benazepril,1,101,0.00980392156862745 Nadolol,1,102,0.009708737864077669 -Ifosfamide,3,311,0.009615384615384616 -Telbivudine,1,103,0.009615384615384616 Lacosamide,1,103,0.009615384615384616 +Ifosfamide,3,311,0.009615384615384616 Telmisartan,2,207,0.009615384615384616 +Telbivudine,1,103,0.009615384615384616 Estradiol valerate/Dienogest,1,104,0.009523809523809525 -Isradipine,1,106,0.009345794392523364 Glipizide,1,106,0.009345794392523364 +Isradipine,1,106,0.009345794392523364 Guanfacine,1,107,0.009259259259259259 Lamivudine,2,216,0.009216589861751152 -Salbutamol,2,217,0.009174311926605505 Olopatadine,1,108,0.009174311926605505 Nicardipine,1,108,0.009174311926605505 +Salbutamol,2,217,0.009174311926605505 Paclitaxel,4,442,0.009029345372460496 Tamoxifen,2,222,0.008968609865470852 Felodipine,1,111,0.008928571428571428 @@ -248,8 +248,8 @@ Apraclonidine,1,112,0.008849557522123894 Zoledronate,2,232,0.008583690987124463 Gemfibrozil,1,116,0.008547008547008548 Budesonide,2,235,0.00847457627118644 -Pioglitazone,1,118,0.008403361344537815 Degarelix,1,118,0.008403361344537815 +Pioglitazone,1,118,0.008403361344537815 Esmolol,1,118,0.008403361344537815 Perindopril,2,239,0.008333333333333333 Nevirapine,1,120,0.008264462809917356 @@ -261,15 +261,15 @@ Penicillamine,1,122,0.008130081300813009 Hydrochlorothiazide,2,246,0.008097165991902834 Ticagrelor,1,123,0.008064516129032258 Pimecrolimus,1,124,0.008 -Goserelin,2,249,0.008 Pemetrexed,1,124,0.008 -Glimepiride,1,126,0.007874015748031496 +Goserelin,2,249,0.008 Gefitinib,1,126,0.007874015748031496 -Conjugated Estrogens,2,255,0.0078125 +Glimepiride,1,126,0.007874015748031496 Sitagliptin,1,127,0.0078125 +Conjugated Estrogens,2,255,0.0078125 Exemestane,1,128,0.007751937984496124 -Nelfinavir,1,130,0.007633587786259542 Acebutolol,1,130,0.007633587786259542 +Nelfinavir,1,130,0.007633587786259542 Stavudine,1,131,0.007575757575757576 Betaxolol,2,263,0.007575757575757576 Labetalol,1,133,0.007462686567164179 @@ -285,30 +285,30 @@ Nisoldipine,1,155,0.00641025641025641 Amlodipine,1,155,0.00641025641025641 Mycophenolate mofetil,3,488,0.006134969325153374 Valproic Acid,2,326,0.0061162079510703364 +Clindamycin,1,163,0.006097560975609756 Sunitinib,2,327,0.006097560975609756 Bromocriptine,1,163,0.006097560975609756 -Clindamycin,1,163,0.006097560975609756 Brimonidine,1,164,0.006060606060606061 Fluticasone Propionate,1,166,0.005988023952095809 Salmeterol,1,167,0.005952380952380952 -Quinidine,1,171,0.005813953488372093 Quinine,1,171,0.005813953488372093 +Quinidine,1,171,0.005813953488372093 Anastrozole,1,172,0.005780346820809248 Letrozole,1,172,0.005780346820809248 Daunorubicin,1,177,0.0056179775280898875 Clofarabine,1,177,0.0056179775280898875 Topiramate,3,535,0.005597014925373134 Propofol,1,178,0.00558659217877095 -Pentostatin,1,179,0.005555555555555556 Anagrelide,1,179,0.005555555555555556 -Estropipate,1,181,0.005494505494505495 -Metoprolol,1,181,0.005494505494505495 +Pentostatin,1,179,0.005555555555555556 Guanabenz,1,181,0.005494505494505495 +Metoprolol,1,181,0.005494505494505495 +Estropipate,1,181,0.005494505494505495 Galantamine,1,184,0.005405405405405406 Dorzolamide,1,184,0.005405405405405406 Nicotine,1,185,0.005376344086021506 -Travoprost,1,186,0.0053475935828877 Zidovudine,1,186,0.0053475935828877 +Travoprost,1,186,0.0053475935828877 Midazolam,1,188,0.005291005291005291 Brinzolamide,1,192,0.0051813471502590676 Levetiracetam,1,194,0.005128205128205128 @@ -323,15 +323,15 @@ Hyoscyamine,1,208,0.004784688995215311 Pilocarpine,1,212,0.004694835680751174 Fosphenytoin,1,212,0.004694835680751174 Quinidine barbiturate,1,221,0.0045045045045045045 -Vandetanib,1,222,0.004484304932735426 Estradiol,2,445,0.004484304932735426 +Vandetanib,1,222,0.004484304932735426 Indinavir,1,223,0.004464285714285714 -Vigabatrin,1,226,0.004405286343612335 Alitretinoin,2,453,0.004405286343612335 +Vigabatrin,1,226,0.004405286343612335 Fenofibrate,1,228,0.004366812227074236 Acamprosate,1,229,0.004347826086956522 -Chenodeoxycholic acid,1,230,0.004329004329004329 Ursodeoxycholic acid,1,230,0.004329004329004329 +Chenodeoxycholic acid,1,230,0.004329004329004329 Pazopanib,1,231,0.004310344827586207 Diazepam,1,235,0.00423728813559322 Clomifene,1,236,0.004219409282700422 @@ -340,8 +340,8 @@ Indapamide,1,243,0.004098360655737705 Diltiazem,1,243,0.004098360655737705 Carvedilol,1,249,0.004 Busulfan,1,254,0.00392156862745098 -Allopurinol,1,255,0.00390625 Felbamate,1,255,0.00390625 +Allopurinol,1,255,0.00390625 Cetirizine,1,255,0.00390625 Doxazosin,1,256,0.0038910505836575876 Efavirenz,1,257,0.003875968992248062 @@ -356,12 +356,12 @@ Acitretin,1,284,0.0035087719298245615 Delavirdine,1,287,0.003472222222222222 Bexarotene,1,288,0.0034602076124567475 Dasatinib,1,288,0.0034602076124567475 -Clonazepam,1,295,0.0033783783783783786 Octreotide,1,295,0.0033783783783783786 +Clonazepam,1,295,0.0033783783783783786 Varenicline,1,297,0.003355704697986577 Phenytoin,1,300,0.0033222591362126247 -Esomeprazole,1,302,0.0033003300330033004 Omeprazole,1,302,0.0033003300330033004 +Esomeprazole,1,302,0.0033003300330033004 Oxcarbazepine,1,304,0.003278688524590164 Progesterone,1,315,0.0031645569620253164 Carbamazepine,1,337,0.0029585798816568047 @@ -377,8 +377,8 @@ Medroxyprogesterone Acetate,1,403,0.0024752475247524753 Riluzole,1,408,0.0024449877750611247 Everolimus,1,417,0.0023923444976076554 Memantine,1,443,0.0022522522522522522 -Isotretinoin,1,453,0.0022026431718061676 Tretinoin,1,453,0.0022026431718061676 +Isotretinoin,1,453,0.0022026431718061676 Rivastigmine,1,468,0.0021321961620469083 Lenalidomide,1,502,0.0019880715705765406 Bupropion,1,520,0.0019193857965451055 diff --git a/neo4j_csv/analysis_symptom_triangle.csv b/neo4j_csv/analysis_symptom_triangle.csv index 5da6f4f..a9e1688 100644 --- a/neo4j_csv/analysis_symptom_triangle.csv +++ b/neo4j_csv/analysis_symptom_triangle.csv @@ -1,95 +1,95 @@ symptom,num_diseases,num_treating_drugs,drugs_with_side_effects,impact_score -Vomiting,38,123,114,4674 -Fatigue,25,137,131,3425 -Psychophysiologic Disorders,18,170,160,3060 -Birth Weight,14,168,159,2352 -Paresthesia,26,87,83,2262 +Edema,49,216,204,10584 +Body Weight,23,169,159,3887 +Fever of Unknown Origin,25,107,98,2675 +Neurologic Manifestations,28,84,79,2352 "Hearing Loss, Sensorineural",24,70,65,1680 -Dyspnea,21,77,75,1617 -Cerebellar Ataxia,17,84,82,1428 -Cough,16,86,83,1376 -"Purpura, Thrombocytopenic, Idiopathic",15,89,83,1335 -Muscular Atrophy,16,81,77,1296 -Sleep Apnea Syndromes,12,95,90,1140 -Ataxia,16,68,67,1088 -Intellectual Disability,17,59,58,1003 -"Purpura, Thrombocytopenic",14,70,64,980 -Flushing,12,75,73,900 -Asthenia,13,68,66,884 -"Obesity, Abdominal",8,108,103,864 -Sciatica,15,50,48,750 -Aphasia,13,57,57,741 -Respiratory Sounds,11,67,66,737 -Ataxia Telangiectasia,13,49,47,637 -Vertigo,13,48,46,624 -"Urinary Bladder, Neurogenic",16,37,36,592 -"Purpura, Thrombotic Thrombocytopenic",7,84,81,588 -Syncope,11,48,47,528 +Constipation,21,75,70,1575 +Polyuria,12,101,96,1212 +Facial Pain,17,66,63,1122 +Sensation Disorders,16,68,64,1088 +Facial Paralysis,19,56,53,1064 +Quadriplegia,17,61,59,1037 +Oral Manifestations,15,62,57,930 +Pelvic Pain,17,49,47,833 +Hearing Disorders,18,46,45,828 +Hemoptysis,16,50,49,800 +Angina Pectoris,8,85,80,680 +Scotoma,12,55,54,660 +Weight Loss,9,62,60,558 +Horner Syndrome,13,42,41,546 +Hearing Loss,15,36,35,540 +Torticollis,14,37,35,518 Hyperventilation,7,74,73,518 +Cyanosis,8,64,63,512 Amnesia,10,50,50,500 Hyperalgesia,10,48,46,480 -Voice Disorders,9,52,51,468 Emaciation,8,57,54,456 -Flatulence,8,53,48,424 -Cerebrospinal Fluid Rhinorrhea,10,39,38,390 -Eye Hemorrhage,8,47,44,376 -"Hearing Loss, High-Frequency",10,37,36,370 +Dysphonia,8,55,53,440 +"Jaundice, Obstructive",14,30,29,420 +Mobility Limitation,9,44,42,396 +Pupil Disorders,10,37,37,370 Chronic Pain,8,46,44,368 -Olfaction Disorders,10,36,36,360 -"Urinary Bladder, Overactive",6,59,58,354 -Color Vision Defects,9,39,39,351 -Acute Coronary Syndrome,6,47,46,282 -Pruritus Ani,6,43,39,258 -Eye Pain,7,36,35,252 +"Purpura, Schoenlein-Henoch",10,36,32,360 +Dystonia,9,37,37,333 +"Gait Disorders, Neurologic",11,26,25,286 +Tonic Pupil,5,57,56,285 +Vitreous Hemorrhage,8,34,33,272 +Agraphia,8,32,32,256 Agnosia,7,36,36,252 -"Hearing Loss, Bilateral",8,30,29,240 -"Hearing Loss, Noise-Induced",3,80,74,240 -"Diarrhea, Infantile",7,34,28,238 +Eye Pain,7,36,35,252 +Perceptual Disorders,11,22,22,242 Tremor,5,46,45,230 -Choroid Hemorrhage,6,34,33,204 -Sarcopenia,5,39,38,195 -"Hearing Loss, Central",6,32,31,192 -Hiccup,7,27,27,189 +"Aging, Premature",6,38,36,228 +"Sleep Apnea, Central",5,45,45,225 +Tinea Pedis,5,43,41,215 +Pain Threshold,7,29,28,203 +"Dyslexia, Acquired",7,27,27,189 +"Aphasia, Wernicke",5,36,36,180 Phantom Limb,6,30,28,180 -Thinness,5,36,35,180 +Hyphema,5,34,33,170 +Cerebrospinal Fluid Leak,7,24,23,168 +Prosopagnosia,5,33,33,165 +Postoperative Nausea and Vomiting,4,39,38,156 +Bulimia,9,17,17,153 Stuttering,6,25,25,150 -Gait Ataxia,6,22,22,132 +Kearns-Sayre Syndrome,5,30,30,150 +Hydrops Fetalis,6,22,22,132 Huntington Disease,8,16,16,128 -"Syncope, Vasovagal",4,32,32,128 -Miosis,4,27,27,108 -Athetosis,3,36,36,108 -"Purpura, Hyperglobulinemic",4,24,20,96 -Metatarsalgia,3,27,25,81 -Toothache,5,16,16,80 -Ageusia,3,26,24,78 -Rett Syndrome,3,25,25,75 +Catalepsy,5,25,25,125 +Chills,3,39,35,117 +Pseudobulbar Palsy,3,37,37,111 +Photophobia,4,27,27,108 +Seizures,3,32,32,96 +Pruritus Vulvae,3,30,28,90 +Sneezing,2,43,42,86 +"Angina, Unstable",3,28,27,84 +Parasomnias,3,25,25,75 +De Lange Syndrome,4,18,14,72 Post-Exercise Hypotension,1,68,63,68 -Fasciculation,4,15,15,60 -Dyssomnias,2,29,28,58 -Hyperemesis Gravidarum,3,18,18,54 +"Paraparesis, Spastic",4,16,16,64 +"Amnesia, Transient Global",2,29,29,58 Respiratory Paralysis,4,13,13,52 -Nocturnal Paroxysmal Dystonia,2,25,25,50 -Hyperesthesia,3,14,13,42 +Muscle Spasticity,4,12,12,48 +Hyperoxia,3,16,16,48 +Hyperphagia,3,15,15,45 +Anomia,4,11,11,44 Gerstmann Syndrome,3,13,13,39 -Polydipsia,4,9,9,36 -Urinoma,3,12,12,36 -Eructation,2,15,13,30 -Ophthalmoplegic Migraine,2,14,14,28 -Sleep Arousal Disorders,1,25,25,25 +Breakthrough Pain,2,18,18,36 +Neuroacanthocytosis,1,25,25,25 Aphonia,3,8,8,24 -Reticulocytosis,2,11,9,22 +Presbycusis,4,6,6,24 Adrenoleukodystrophy,2,11,11,22 -Muscle Hypertonia,2,11,11,22 -Halitosis,4,4,4,16 -"Apraxia, Ideomotor",3,5,5,15 +WAGR Syndrome,1,13,13,13 Orthostatic Intolerance,1,11,11,11 -Prader-Willi Syndrome,1,11,11,11 -Susac Syndrome,1,11,11,11 "Aphasia, Primary Progressive",2,4,4,8 -Benign Paroxysmal Positional Vertigo,1,7,7,7 -Anhedonia,4,1,1,4 -Striae Distensae,1,2,2,2 -Fetal Weight,2,1,1,2 -Wolfram Syndrome,1,1,1,1 -"Dyskinesia, Drug-Induced",5,0,0,0 -Nocturnal Myoclonus Syndrome,5,0,0,0 +Alice in Wonderland Syndrome,1,7,7,7 +Usher Syndromes,2,2,2,4 +Waterhouse-Friderichsen Syndrome,1,0,0,0 +"Polydipsia, Psychogenic",1,0,0,0 +Gait Apraxia,1,0,0,0 +Machado-Joseph Disease,2,0,0,0 +Alien Hand Syndrome,1,0,0,0 +Lipoid Proteinosis of Urbach and Wiethe,1,0,0,0 +"Akathisia, Drug-Induced",7,0,0,0 +Systolic Murmurs,1,0,0,0 diff --git a/neo4j_csv/edges_associates.csv b/neo4j_csv/edges_associates.csv new file mode 100644 index 0000000..39c0b0d --- 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+UBERON:0000997,84830 +UBERON:0000002,1495 +UBERON:0002037,10982 +UBERON:0002185,2113 +UBERON:0000948,5348 +DB01204,11000 +UBERON:0000029,54916 +DOID:263,857 +UBERON:0000955,53841 +UBERON:0002048,79931 +UBERON:0001235,5915 +UBERON:0000178,160365 +DB04865,64376 +UBERON:0001296,22887 +DB08912,1052 +UBERON:0002371,64078 +UBERON:0002048,11067 +UBERON:0002240,5690 +UBERON:0001675,8036 +UBERON:0001295,51631 +UBERON:0002240,3707 +UBERON:0001296,51433 +DB00390,23764 +UBERON:0000029,5551 +DB00374,51422 +UBERON:0002046,2900 +UBERON:0001295,169841 +UBERON:0002048,1630 +UBERON:0002081,5506 +UBERON:0002030,63970 diff --git a/neo4j_etl.py b/neo4j_etl.py new file mode 100644 index 0000000..2cd183a --- /dev/null +++ b/neo4j_etl.py @@ -0,0 +1,81 @@ +from neo4j import GraphDatabase +import pandas as pd +import os +import glob +import getpass + + +# Neo4j Connection + +NEO4J_URI = "bolt://localhost:7687" +NEO4J_USER = input("Neo4j username: ") +NEO4J_PASSWORD = getpass.getpass("Neo4j password: ") + +driver = GraphDatabase.driver( + NEO4J_URI, + auth=(NEO4J_USER, NEO4J_PASSWORD) +) + + +# Helper Functions + + +def test_connection(): + try: + with driver.session() as session: + result = session.run("RETURN 1") + if result.single(): + print("✓ Connection successful") + return True + else: + print("✗ Error connecting") + return False + except Exception as e: + print(f"✗ Error with the connection: {e}") + return False + +def run_query(query, parameters=None): + """Run a Cypher query and return a Pandas DataFrame""" + with driver.session() as session: + result = session.run(query, parameters) + df = pd.DataFrame([record.data() for record in result]) + return df + + +# Check Neo4j connection + +if not test_connection(): + print("Cannot connect to Neo4j") + exit(1) + + +# Folder for results + +output_dir = "query_results" +os.makedirs(output_dir, exist_ok=True) + + +# Run all .cypher files in 'queries/' folder + +cypher_files = sorted(glob.glob("analysis_queries/*.cypher")) + +for file in cypher_files: + with open(file, "r", encoding="utf-8") as f: + query = f.read() + print(f"\nRunning {file}") + try: + df = run_query(query) + if df.empty: + print("⚠ No results returned") + else: + print(df.head(5)) # show top 5 rows + safe_name = os.path.splitext(os.path.basename(file))[0] + csv_path = os.path.join(output_dir, f"{safe_name}.csv") + df.to_csv(csv_path, index=False, encoding="utf-8-sig") + print(f"✓ Saved to {csv_path}") + except Exception as e: + print(f"✗ Error running query '{file}': {e}") + + +driver.close() +print("\nAll queries executed.") diff --git a/neo4jqueries/analysis_queries/query1.cypher b/neo4jqueries/analysis_queries/query1.cypher new file mode 100644 index 0000000..bc297ce --- /dev/null +++ b/neo4jqueries/analysis_queries/query1.cypher @@ -0,0 +1,6 @@ +// Drug similarity based on shared targets +MATCH (c1:Compound)-[:BINDS]->(g:Gene)<-[:BINDS]-(c2:Compound) +WHERE c1 <> c2 +RETURN c1.name AS Drug1, c2.name AS Drug2, count(g) AS SharedGenes +ORDER BY SharedGenes DESC +LIMIT 20; diff --git a/neo4jqueries/analysis_queries/query2.cypher b/neo4jqueries/analysis_queries/query2.cypher new file mode 100644 index 0000000..2b4963e --- /dev/null +++ b/neo4jqueries/analysis_queries/query2.cypher @@ -0,0 +1,4 @@ +// Get count of nodes +MATCH (n) +RETURN labels(n) AS NodeType, count(*) AS Count +ORDER BY Count DESC; diff --git a/neo4jqueries/analysis_queries/query3.cypher b/neo4jqueries/analysis_queries/query3.cypher new file mode 100644 index 0000000..c1246ff --- /dev/null +++ b/neo4jqueries/analysis_queries/query3.cypher @@ -0,0 +1,5 @@ +// Drugs treating diseases that present specific symptoms +MATCH (s:Symptom)<-[:PRESENTS]-(d:Disease)<-[:TREATS]-(c:Compound) +RETURN s.name AS Symptom, c.name AS Drug, count(d) AS DiseaseCount +ORDER BY DiseaseCount DESC +LIMIT 20; diff --git a/neo4jqueries/analysis_queries/query4.cypher b/neo4jqueries/analysis_queries/query4.cypher new file mode 100644 index 0000000..fdf8df1 --- /dev/null +++ b/neo4jqueries/analysis_queries/query4.cypher @@ -0,0 +1,5 @@ +// Top 10 diseases with the most associated symptoms +MATCH (d:Disease)-[:PRESENTS]->(s:Symptom) +RETURN d.name AS Disease, count(s) AS SymptomCount +ORDER BY SymptomCount DESC +LIMIT 10; diff --git a/neo4jqueries/analysis_queries/query5.cypher b/neo4jqueries/analysis_queries/query5.cypher new file mode 100644 index 0000000..bd27a2d --- /dev/null +++ b/neo4jqueries/analysis_queries/query5.cypher @@ -0,0 +1,9 @@ +// Drugs sharing the same side effects showing potential conflicts +MATCH (c1:Compound)-[:BINDS]->(:Gene), + (c1)-[:TREATS]->(:Disease), + (c1)-[:TREATS]->(:Disease)<-[:TREATS]-(c2:Compound), + (c1)-[:BINDS]->(g:Gene) +WHERE c1 <> c2 +RETURN c1.name AS Drug1, c2.name AS Drug2, count(g) AS SharedTargets +ORDER BY SharedTargets DESC +LIMIT 20; diff --git a/neo4jqueries/analysis_queries/query6.cypher b/neo4jqueries/analysis_queries/query6.cypher new file mode 100644 index 0000000..34afcef --- /dev/null +++ b/neo4jqueries/analysis_queries/query6.cypher @@ -0,0 +1,5 @@ +// Top 10 Drugs treating multiple Diseases +MATCH (c:Compound)-[:TREATS]->(d:Disease) +RETURN c.name AS Drug, count(d) AS DiseaseCount +ORDER BY DiseaseCount DESC +LIMIT 10; diff --git a/neo4jqueries/analysis_queries/query7.cypher b/neo4jqueries/analysis_queries/query7.cypher new file mode 100644 index 0000000..8590c33 --- /dev/null +++ b/neo4jqueries/analysis_queries/query7.cypher @@ -0,0 +1,7 @@ +// Drugs treating diseases connected to the same genes +MATCH (g:Gene)<-[:ASSOCIATES]-(d1:Disease)<-[:TREATS]-(c:Compound), + (g)<-[:ASSOCIATES]-(d2:Disease) +WHERE NOT (c)-[:TREATS]->(d2) +RETURN c.name AS Drug, d2.name AS CandidateDisease, count(g) AS SharedGenes +ORDER BY SharedGenes DESC, Drug +LIMIT 20; diff --git a/neo4jqueries/analysis_queries/query8.cypher b/neo4jqueries/analysis_queries/query8.cypher new file mode 100644 index 0000000..3b0ca97 --- /dev/null +++ b/neo4jqueries/analysis_queries/query8.cypher @@ -0,0 +1,4 @@ +// LOOK for 999 Treatments for diseases +MATCH p=()-[:TREATS]->() +RETURN p +LIMIT 999; diff --git a/neo4jqueries/loadingQueriesNeo4j/LoadNodes.cypher b/neo4jqueries/loadingQueriesNeo4j/LoadNodes.cypher new file mode 100644 index 0000000..006a9dd --- /dev/null +++ b/neo4jqueries/loadingQueriesNeo4j/LoadNodes.cypher @@ -0,0 +1,19 @@ +// Genes +LOAD CSV WITH HEADERS FROM 'file:///nodes_Gene.csv' AS row +CREATE (g:Gene) SET g = row; + +// Diseases +LOAD CSV WITH HEADERS FROM 'file:///nodes_Disease.csv' AS row +CREATE (d:Disease) SET d = row; + +// Compounds +LOAD CSV WITH HEADERS FROM 'file:///nodes_Compound.csv' AS row +CREATE (c:Compound) SET c = row; + +// Symptoms +LOAD CSV WITH HEADERS FROM 'file:///nodes_Symptom.csv' AS row +CREATE (s:Symptom) SET s = row; + +// Side Effects +LOAD CSV WITH HEADERS FROM 'file:///nodes_Side_Effect.csv' AS row +CREATE (se:Side_Effect) SET se = row; \ No newline at end of file diff --git a/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Associates copy.cypher b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Associates copy.cypher new file mode 100644 index 0000000..431f213 --- /dev/null +++ b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Associates copy.cypher @@ -0,0 +1,4 @@ +LOAD CSV WITH HEADERS FROM 'file:///edges_treats.csv' AS row +MATCH (source {id: row.source}) +MATCH (target {id: row.target}) +CREATE (source)-[:TREATS]->(target); \ No newline at end of file diff --git a/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Binds.cypher b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Binds.cypher new file mode 100644 index 0000000..ff57f4c --- /dev/null +++ b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Binds.cypher @@ -0,0 +1,4 @@ +LOAD CSV WITH HEADERS FROM 'file:///edges_binds.csv' AS row +MATCH (source {id: row.source}) +MATCH (target {id: row.target}) +CREATE (source)-[:BINDS]->(target); \ No newline at end of file diff --git a/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Causes copy 2.cypher b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Causes copy 2.cypher new file mode 100644 index 0000000..99882c5 --- /dev/null +++ b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Causes copy 2.cypher @@ -0,0 +1,4 @@ +LOAD CSV WITH HEADERS FROM 'file:///edges_interacts.csv' AS row +MATCH (source {id: row.source}) +MATCH (target {id: row.target}) +CREATE (source)-[:INTERACTS]->(target); \ No newline at end of file diff --git a/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Covaries.cypher b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Covaries.cypher new file mode 100644 index 0000000..e39bc9d --- /dev/null +++ b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Covaries.cypher @@ -0,0 +1,4 @@ +LOAD CSV WITH HEADERS FROM 'file:///edges_covaries.csv' AS row +MATCH (source {id: row.source}) +MATCH (target {id: row.target}) +CREATE (source)-[:COVARIES]->(target); \ No newline at end of file diff --git a/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Interacts.cypher b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Interacts.cypher new file mode 100644 index 0000000..b4258d7 --- /dev/null +++ b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Interacts.cypher @@ -0,0 +1,4 @@ +LOAD CSV WITH HEADERS FROM 'file:///edges_causes.csv' AS row +MATCH (source {id: row.source}) +MATCH (target {id: row.target}) +CREATE (source)-[:CAUSES]->(target); \ No newline at end of file diff --git a/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Upregulates.cypher b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Upregulates.cypher new file mode 100644 index 0000000..b4258d7 --- /dev/null +++ b/neo4jqueries/loadingQueriesNeo4j/LoadRelationshipsEdges_Upregulates.cypher @@ -0,0 +1,4 @@ +LOAD CSV WITH HEADERS FROM 'file:///edges_causes.csv' AS row +MATCH (source {id: row.source}) +MATCH (target {id: row.target}) +CREATE (source)-[:CAUSES]->(target); \ No newline at end of file